Abstract
Two new nonsense suppressors in Escherichia coli were found in partial diploids carrying F′14 and were shown to be on the episome. These suppressors can exist only in cells which also contain the su - allele, i.e., su + / su - heterozygotes. Presumably the mutations cause an alteration of an essential cellular component, the complete loss of which is lethal. Su 7, an amber suppressor, has an efficiency of 76 per cent and su 8, an ochre suppressor, an efficiency of 4 per cent.
Dates
Type | When |
---|---|
Created | 19 years, 2 months ago (May 31, 2006, 2:13 a.m.) |
Deposited | 3 years, 4 months ago (April 13, 2022, 10:01 a.m.) |
Indexed | 4 months, 3 weeks ago (April 4, 2025, 1:09 p.m.) |
Issued | 56 years, 2 months ago (June 1, 1969) |
Published | 56 years, 2 months ago (June 1, 1969) |
Published Online | 56 years, 2 months ago (June 1, 1969) |
Published Print | 56 years, 2 months ago (June 1, 1969) |
@article{Soll_1969, title={RECESSIVE LETHALS: A NEW CLASS OF NONSENSE SUPPRESSORS IN Escherichia coli}, volume={63}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.63.2.392}, DOI={10.1073/pnas.63.2.392}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Soll, Larry and Berg, Paul}, year={1969}, month=jun, pages={392–399} }