DOI: 10.1073/pnas.63.1.93. RELEASE OF TRANSFER RNA DURING PEPTIDE CHAIN ELONGATION

RELEASE OF TRANSFER RNA DURING PEPTIDE CHAIN ELONGATION

10.1073/pnas.63.1.93

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In amino acid polymerization, the tRNA donating its peptidyl moiety to the neighboring aminoacyl-tRNA must be released from the ribosome for further growth of the polypeptide chain. It was not known at what stage of peptide elongation this tRNA is released. To study this question, we prepared ac-C 14 -Phe-H 3 -tRNA using H 3 -tRNA isolated from E. coli strain 15THU grown in the presence of H 3 -uracil, and followed the fate of the H 3 -tRNA during chain growth. Our results indicate that donor tRNA is released during the translocation step, mediated by the soluble factor G and GTP.

Bibliography

Lucas-Lenard, J., & Haenni, A.-L. (1969). RELEASE OF TRANSFER RNA DURING PEPTIDE CHAIN ELONGATION. Proceedings of the National Academy of Sciences, 63(1), 93â97.

Authors 2

Jean Lucas-Lenard (first)
Anne-Lise Haenni (additional)

References 0 Referenced 51

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 2:13 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:08 a.m.)
Indexed	1 year, 9 months ago (Nov. 23, 2023, 1:34 p.m.)
Issued	56 years, 3 months ago (May 1, 1969)
Published	56 years, 3 months ago (May 1, 1969)
Published Online	56 years, 3 months ago (May 1, 1969)
Published Print	56 years, 3 months ago (May 1, 1969)

Funders 0

None

BibTeX

@article{Lucas_Lenard_1969, title={RELEASE OF TRANSFER RNA DURING PEPTIDE CHAIN ELONGATION}, volume={63}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.63.1.93}, DOI={10.1073/pnas.63.1.93}, number={1}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Lucas-Lenard, Jean and Haenni, Anne-Lise}, year={1969}, month=may, pages={93–97} }

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