DOI: 10.1073/pnas.62.2.597. DEOXYRIBONUCLEASE IV: A NEW EXONUCLEASE FROM MAMMALIAN TISSUES

DEOXYRIBONUCLEASE IV: A NEW EXONUCLEASE FROM MAMMALIAN TISSUES

10.1073/pnas.62.2.597

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

An exonuclease which specifically degrades double-standard DNA has been isolated from rabbit tissues. The enzyme has an approximate molecular weight of 42,000, requires a divalent metal ion as cofactor, and attacks DNA at the 5′-terminal ends, thereby liberating 5′-mononucleotides. It degrades several synthetic polydeoxynucleotides of single repeating base sequences more rapidly than DNA from natural sources. The specificity of this mammalian enzyme resembles that of several microbial enzymes (phage λ exonuclease and DNA polymerase) which appear to be required for repair and recombination of DNA.

Bibliography

Lindahl, T., Gally, J. A., & Edelman, G. M. (1969). DEOXYRIBONUCLEASE IV: A NEW EXONUCLEASE FROM MAMMALIAN TISSUES. Proceedings of the National Academy of Sciences, 62(2), 597â603.

Authors 3

Tomas Lindahl (first)
Joseph A. Gally (additional)
Gerald M. Edelman (additional)

References 0 Referenced 76

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 2:11 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 10:18 a.m.)
Indexed	1 year, 1 month ago (July 22, 2024, 8:10 p.m.)
Issued	56 years, 7 months ago (Feb. 1, 1969)
Published	56 years, 7 months ago (Feb. 1, 1969)
Published Online	56 years, 7 months ago (Feb. 1, 1969)
Published Print	56 years, 7 months ago (Feb. 1, 1969)

Funders 0

None

BibTeX

@article{Lindahl_1969, title={DEOXYRIBONUCLEASE IV: A NEW EXONUCLEASE FROM MAMMALIAN TISSUES}, volume={62}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.62.2.597}, DOI={10.1073/pnas.62.2.597}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Lindahl, Tomas and Gally, Joseph A. and Edelman, Gerald M.}, year={1969}, month=feb, pages={597–603} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        7,
        23
      ]
    ],
    "date-time": "2024-07-23T00:10:11Z",
    "timestamp": 1721693411013
  },
  "reference-count": 0,
  "publisher": "Proceedings of the National Academy of Sciences",
  "issue": "2",
  "content-domain": {
    "domain": [
      "www.pnas.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1969,
        2
      ]
    ]
  },
  "abstract": "<jats:p>An exonuclease which specifically degrades double-standard DNA has been isolated from rabbit tissues. The enzyme has an approximate molecular weight of 42,000, requires a divalent metal ion as cofactor, and attacks DNA at the 5\u2032-terminal ends, thereby liberating 5\u2032-mononucleotides. It degrades several synthetic polydeoxynucleotides of single repeating base sequences more rapidly than DNA from natural sources. The specificity of this mammalian enzyme resembles that of several microbial enzymes (phage \u03bb exonuclease and DNA polymerase) which appear to be required for repair and recombination of DNA.</jats:p>",
  "DOI": "10.1073/pnas.62.2.597",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        5,
        31
      ]
    ],
    "date-time": "2006-05-31T06:11:12Z",
    "timestamp": 1149055872000
  },
  "page": "597-603",
  "update-policy": "http://dx.doi.org/10.1073/pnas.cm10313",
  "source": "Crossref",
  "is-referenced-by-count": 76,
  "title": "DEOXYRIBONUCLEASE IV: A NEW EXONUCLEASE FROM MAMMALIAN TISSUES",
  "prefix": "10.1073",
  "volume": "62",
  "author": [
    {
      "given": "Tomas",
      "family": "Lindahl",
      "sequence": "first",
      "affiliation": [
        {
          "name": "THE ROCKEFELLER UNIVERSITY"
        }
      ]
    },
    {
      "given": "Joseph A.",
      "family": "Gally",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "THE ROCKEFELLER UNIVERSITY"
        }
      ]
    },
    {
      "given": "Gerald M.",
      "family": "Edelman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "THE ROCKEFELLER UNIVERSITY"
        }
      ]
    }
  ],
  "member": "341",
  "published-online": {
    "date-parts": [
      [
        1969,
        2
      ]
    ]
  },
  "container-title": "Proceedings of the National Academy of Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pnas.org/doi/pdf/10.1073/pnas.62.2.597",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        4,
        13
      ]
    ],
    "date-time": "2022-04-13T14:18:18Z",
    "timestamp": 1649859498000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pnas.org/doi/full/10.1073/pnas.62.2.597"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1969,
        2
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1969,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1073/pnas.62.2.597"
  ],
  "URL": "http://dx.doi.org/10.1073/pnas.62.2.597",
  "relation": {},
  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        1969,
        2
      ]
    ]
  },
  "assertion": [
    {
      "value": "1969-02-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}