DOI: 10.1073/pnas.242597199. Memory-specific temporal profiles of gene expression in the hippocampus

Memory-specific temporal profiles of gene expression in the hippocampus

10.1073/pnas.242597199

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Many experiments in the past have demonstrated the requirement of de novo gene expression during the long-term retention of learning and memory. Although previous studies implicated individual genes or genetic pathways in learning and memory, they did not uncover the collective behaviors or patterns of the genes. We have used genome-scale screening to analyze gene expression during spatial learning of rats in the Morris water maze. Our results show distinct temporal gene expression profiles associated with learning and memory. Exogenous administration of one peptide whose sustained increase during memory retention was implicated by microarray analysis, fibroblast growth factor (FGF)-18, improved spatial learning behavior, suggesting that pharmacological modulation of pathways and targets identified may allow new therapeutic approaches for improving learning and memory. Results of this study also suggest that while learning and physical activity involve common groups of genes, the behavior of learning and memory emerges from unique patterns of gene expression across time.

Bibliography

Cavallaro, S., DâAgata, V., Manickam, P., Dufour, F., & Alkon, D. L. (2002). Memory-specific temporal profiles of gene expression in the hippocampus. Proceedings of the National Academy of Sciences, 99(25), 16279â16284.

Authors 5

Sebastiano Cavallaro (first)
Velia D'Agata (additional)
Pachiappan Manickam (additional)
Franck Dufour (additional)
Daniel L. Alkon (additional)

References 54 Referenced 157

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Dates

Type	When
Created	22 years, 8 months ago (Dec. 10, 2002, 12:42 p.m.)
Deposited	3 years, 4 months ago (April 25, 2022, 8:58 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:45 a.m.)
Issued	22 years, 8 months ago (Dec. 2, 2002)
Published	22 years, 8 months ago (Dec. 2, 2002)
Published Online	22 years, 8 months ago (Dec. 2, 2002)
Published Print	22 years, 8 months ago (Dec. 10, 2002)

Funders 0

None

BibTeX

@article{Cavallaro_2002, title={Memory-specific temporal profiles of gene expression in the hippocampus}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.242597199}, DOI={10.1073/pnas.242597199}, number={25}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Cavallaro, Sebastiano and D’Agata, Velia and Manickam, Pachiappan and Dufour, Franck and Alkon, Daniel L.}, year={2002}, month=dec, pages={16279–16284} }

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