DOI: 10.1073/pnas.232693499. Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients

Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients

10.1073/pnas.232693499

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The delineation of dopamine dysfunction in the mentally ill has been a long-standing quest of biological psychiatry. The present study focuses on a recently recognized group of dopamine receptor-interacting proteins as possible novel sites of dysfunction in schizophrenic and bipolar patients. We demonstrate that the dorsolateral prefrontal cortex in schizophrenia and bipolar cases from the Stanley Foundation Neuropathology Consortium display significantly elevated levels of the D2 dopamine receptor desensitization regulatory protein, neuronal calcium sensor-1. These levels of neuronal calcium sensor-1 were not influenced by age, gender, hemisphere, cause of death, postmortem period, alcohol consumption, or antipsychotic and mood stabilizing medications. The present study supports the hypothesis that schizophrenia and bipolar disorder may be associated with abnormalities in dopamine receptor-interacting proteins.

Bibliography

Koh, P. O., Undie, A. S., Kabbani, N., Levenson, R., Goldman-Rakic, P. S., & Lidow, M. S. (2002). Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients. Proceedings of the National Academy of Sciences, 100(1), 313â317.

Authors 6

Phil Ok Koh (first)
Ashiwel S. Undie (additional)
Nadine Kabbani (additional)
Robert Levenson (additional)
Patricia S. Goldman-Rakic (additional)
Michael S. Lidow (additional)

References 63 Referenced 175

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Dates

Type	When
Created	22 years, 7 months ago (Jan. 7, 2003, 12:22 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 9:17 a.m.)
Indexed	3 weeks, 5 days ago (Aug. 5, 2025, 8:20 a.m.)
Issued	22 years, 8 months ago (Dec. 20, 2002)
Published	22 years, 8 months ago (Dec. 20, 2002)
Published Online	22 years, 8 months ago (Dec. 20, 2002)
Published Print	22 years, 7 months ago (Jan. 7, 2003)

Funders 0

None

BibTeX

@article{Koh_2002, title={Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients}, volume={100}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.232693499}, DOI={10.1073/pnas.232693499}, number={1}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Koh, Phil Ok and Undie, Ashiwel S. and Kabbani, Nadine and Levenson, Robert and Goldman-Rakic, Patricia S. and Lidow, Michael S.}, year={2002}, month=dec, pages={313–317} }

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