DOI: 10.1073/pnas.232389399. DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the <i>Drosophila</i> ovary

DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary

10.1073/pnas.232389399

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Evidence from many systems has shown that stem cells are maintained in “niches” or specific regulatory microenvironments formed by stromal cells. The question of how stem cells are maintained in their niches is important, and further studies will lead to a better understanding of stem cell regulation and enhance the future use of stem cells in regenerative medicine. Here we show that cadherin-mediated cell adhesion is required for anchoring somatic stem cells (SSCs) to their niches in the Drosophila ovary. DE-cadherin and Armadillo/β-catenin accumulate in the junctions between SSCs and their neighboring cells, inner germarial sheath cells. Removal of DE-cadherin from SSCs results in stem cell loss in the adult ovary. Furthermore, the cadherin-mediated adhesion is also important for maintaining SSCs in their niches before adulthood. This study provides further support that SSCs are located in a niche formed by their neighboring cells. We have previously shown that DE-cadherin-mediated cell adhesion is essential for anchoring germ-line stem cells to their niches in the Drosophila ovary. This study further implicates cadherin-mediated cell adhesion as a general mechanism for anchoring stem cells to their niches in a variety of systems.

Bibliography

Song, X., & Xie, T. (2002). DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary. Proceedings of the National Academy of Sciences, 99(23), 14813â14818.

Authors 2

Xiaoqing Song (first)
Ting Xie (additional)

References 34 Referenced 203

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Dates

Type	When
Created	22 years, 9 months ago (Nov. 12, 2002, 1:44 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 9:30 a.m.)
Indexed	1 day, 11 hours ago (Aug. 29, 2025, 6:14 a.m.)
Issued	22 years, 10 months ago (Oct. 22, 2002)
Published	22 years, 10 months ago (Oct. 22, 2002)
Published Online	22 years, 10 months ago (Oct. 22, 2002)
Published Print	22 years, 9 months ago (Nov. 12, 2002)

Funders 0

None

BibTeX

@article{Song_2002, title={DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.232389399}, DOI={10.1073/pnas.232389399}, number={23}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Song, Xiaoqing and Xie, Ting}, year={2002}, month=oct, pages={14813–14818} }

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