DOI: 10.1073/pnas.231625398. Stereotyped and specific gene expression programs in human innate immune responses to bacteria

Stereotyped and specific gene expression programs in human innate immune responses to bacteria

10.1073/pnas.231625398

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of the gene expression program in human peripheral blood mononuclear cells responding to bacteria and bacterial products. We found a remarkably stereotyped program of gene expression induced by bacterial lipopolysaccharide and diverse killed bacteria. An intricately choreographed expression program devoted to communication between cells was a prominent feature of the response. Other features suggested a molecular program for commitment of antigen-presenting cells to antigens captured in the context of bacterial infection. Despite the striking similarities, there were qualitative and quantitative differences in the responses to different bacteria. Modulation of this host-response program by bacterial virulence mechanisms was an important source of variation in the response to different bacteria.

Bibliography

Boldrick, J. C., Alizadeh, A. A., Diehn, M., Dudoit, S., Liu, C. L., Belcher, C. E., Botstein, D., Staudt, L. M., Brown, P. O., & Relman, D. A. (2002). Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proceedings of the National Academy of Sciences, 99(2), 972â977.

Authors 10

Jennifer C. Boldrick (first)
Ash A. Alizadeh (additional)
Maximilian Diehn (additional)
Sandrine Dudoit (additional)
Chih Long Liu (additional)
Christopher E. Belcher (additional)
David Botstein (additional)
Louis M. Staudt (additional)
Patrick O. Brown (additional)
David A. Relman (additional)

References 39 Referenced 314

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:36 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:17 a.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 7:54 a.m.)
Issued	23 years, 7 months ago (Jan. 22, 2002)
Published	23 years, 7 months ago (Jan. 22, 2002)
Published Online	23 years, 7 months ago (Jan. 22, 2002)
Published Print	23 years, 7 months ago (Jan. 22, 2002)

Funders 0

None

BibTeX

@article{Boldrick_2002, title={Stereotyped and specific gene expression programs in human innate immune responses to bacteria}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.231625398}, DOI={10.1073/pnas.231625398}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Boldrick, Jennifer C. and Alizadeh, Ash A. and Diehn, Maximilian and Dudoit, Sandrine and Liu, Chih Long and Belcher, Christopher E. and Botstein, David and Staudt, Louis M. and Brown, Patrick O. and Relman, David A.}, year={2002}, month=jan, pages={972–977} }

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