DOI: 10.1073/pnas.231442498. Expression of <i>Borrelia burgdorferi</i> OspC and DbpA is controlled by a RpoN

Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN–RpoS regulatory pathway

10.1073/pnas.231442498

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

RpoS and RpoN are two alternative sigma factors typically associated with general stress responses in bacteria. To date, there has been no experimental evidence that RpoS and RpoN can directly control the expression of one another. Herein, using a combined strategy of gene disruption and genetic complementation targeting rpoN and rpoS in Borrelia burgdorferi strain 297, we describe a regulatory network for B. burgdorferi . In this network, RpoN controls the expression of RpoS, which, in turn, governs the expression of two important membrane lipoproteins, outer surface protein C and decorin-binding protein A, and likely other proteins of B. burgdorferi . Our findings provide a foundation for elucidating further key regulatory networks that potentially impact many aspects of B. burgdorferi 's parasitic strategy, host range, and virulence expression.

Bibliography

HÃ¼bner, A., Yang, X., Nolen, D. M., Popova, T. G., Cabello, F. C., & Norgard, M. V. (2001). Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoNâRpoS regulatory pathway. Proceedings of the National Academy of Sciences, 98(22), 12724â12729.

Authors 6

Anette Hübner (first)
Xiaofeng Yang (additional)
Dena M. Nolen (additional)
Taissia G. Popova (additional)
Felipe C. Cabello (additional)
Michael V. Norgard (additional)

References 51 Referenced 296

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:34 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 9:23 a.m.)
Indexed	1 day, 16 hours ago (Sept. 3, 2025, 5:59 a.m.)
Issued	23 years, 10 months ago (Oct. 23, 2001)
Published	23 years, 10 months ago (Oct. 23, 2001)
Published Online	23 years, 10 months ago (Oct. 23, 2001)
Published Print	23 years, 10 months ago (Oct. 23, 2001)

Funders 0

None

BibTeX

@article{H_bner_2001, title={Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN–RpoS regulatory pathway}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.231442498}, DOI={10.1073/pnas.231442498}, number={22}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hübner, Anette and Yang, Xiaofeng and Nolen, Dena M. and Popova, Taissia G. and Cabello, Felipe C. and Norgard, Michael V.}, year={2001}, month=oct, pages={12724–12729} }

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