DOI: 10.1073/pnas.212527899. Inositol pyrophosphates regulate endocytic trafficking

Inositol pyrophosphates regulate endocytic trafficking

10.1073/pnas.212527899

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic membrane defects selectively associated with deficient formation of inositol pyrophosphates. We show that this phenotype reflects specific abnormalities in endocytic pathways and not other components of membrane trafficking. Thus, inositol pyrophosphates are major regulators of endocytosis.

Bibliography

Saiardi, A., Sciambi, C., McCaffery, J. M., Wendland, B., & Snyder, S. H. (2002). Inositol pyrophosphates regulate endocytic trafficking. Proceedings of the National Academy of Sciences, 99(22), 14206â14211.

Authors 5

Adolfo Saiardi (first)
Catherine Sciambi (additional)
J. Michael McCaffery (additional)
Beverly Wendland (additional)
Solomon H. Snyder (additional)

References 36 Referenced 147

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Dates

Type	When
Created	22 years, 10 months ago (Oct. 29, 2002, 12:24 p.m.)
Deposited	3 years, 4 months ago (April 25, 2022, 9:07 p.m.)
Indexed	6 days, 13 hours ago (Aug. 30, 2025, 12:44 p.m.)
Issued	22 years, 10 months ago (Oct. 21, 2002)
Published	22 years, 10 months ago (Oct. 21, 2002)
Published Online	22 years, 10 months ago (Oct. 21, 2002)
Published Print	22 years, 10 months ago (Oct. 29, 2002)

Funders 0

None

BibTeX

@article{Saiardi_2002, title={Inositol pyrophosphates regulate endocytic trafficking}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.212527899}, DOI={10.1073/pnas.212527899}, number={22}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Saiardi, Adolfo and Sciambi, Catherine and McCaffery, J. Michael and Wendland, Beverly and Snyder, Solomon H.}, year={2002}, month=oct, pages={14206–14211} }

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