DOI: 10.1073/pnas.202035899. Reelin, Disabled 1, and β <sub>1</sub> integrins are required for the formation of the radial glial scaffold in the hippocampus

Reelin, Disabled 1, and β 1 integrins are required for the formation of the radial glial scaffold in the hippocampus

10.1073/pnas.202035899

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The extracellular matrix molecule Reelin is required for the correct positioning of neurons during the development of the forebrain. However, the mechanism of Reelin action on neuronal migration is poorly understood. Reelin is assumed to act on neurons directly, but it may also affect the differentiation of glial cells necessary for neuronal migration. Here we show that a regular glial scaffold fails to form in vivo in the dentate gyrus of mice deficient of Reelin or Disabled 1, a neuronal adaptor protein in the Reelin signaling pathway. A subset of these defects is observed in mice that lack β 1 -class integrins, known to bind Reelin. Moreover, recombinant Reelin induced branching of glial processes in vitro . Our data suggest that Reelin affects glial differentiation via Disabled 1 and β 1 -class integrin-dependent signaling pathways.

Bibliography

FÃ¶rster, E., Tielsch, A., Saum, B., Weiss, K. H., Johanssen, C., Graus-Porta, D., MÃ¼ller, U., & Frotscher, M. (2002). Reelin, Disabled 1, and Î² 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. Proceedings of the National Academy of Sciences, 99(20), 13178â13183.

Authors 8

Eckart Förster (first)
Albrecht Tielsch (additional)
Barbara Saum (additional)
Karl Heinz Weiss (additional)
Celine Johanssen (additional)
Diana Graus-Porta (additional)
Ulrich Müller (additional)
Michael Frotscher (additional)

References 49 Referenced 203

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Dates

Type	When
Created	22 years, 11 months ago (Oct. 1, 2002, 12:58 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 6:42 a.m.)
Indexed	2 days, 12 hours ago (Sept. 3, 2025, 6:12 a.m.)
Issued	22 years, 11 months ago (Sept. 20, 2002)
Published	22 years, 11 months ago (Sept. 20, 2002)
Published Online	22 years, 11 months ago (Sept. 20, 2002)
Published Print	22 years, 11 months ago (Oct. 1, 2002)

Funders 0

None

BibTeX

@article{F_rster_2002, title={Reelin, Disabled 1, and β 1 integrins are required for the formation of the radial glial scaffold in the hippocampus}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.202035899}, DOI={10.1073/pnas.202035899}, number={20}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Förster, Eckart and Tielsch, Albrecht and Saum, Barbara and Weiss, Karl Heinz and Johanssen, Celine and Graus-Porta, Diana and Müller, Ulrich and Frotscher, Michael}, year={2002}, month=sep, pages={13178–13183} }

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