DOI: 10.1073/pnas.191367098. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

10.1073/pnas.191367098

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics to clinical outcome. A total of 85 cDNA microarray experiments representing 78 cancers, three fibroadenomas, and four normal breast tissues were analyzed by hierarchical clustering. As reported previously, the cancers could be classified into a basal epithelial-like group, an ERBB2 -overexpressing group and a normal breast-like group based on variations in gene expression. A novel finding was that the previously characterized luminal epithelial/estrogen receptor-positive group could be divided into at least two subgroups, each with a distinctive expression profile. These subtypes proved to be reasonably robust by clustering using two different gene sets: first, a set of 456 cDNA clones previously selected to reflect intrinsic properties of the tumors and, second, a gene set that highly correlated with patient outcome. Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.

Bibliography

SÃ¸rlie, T., Perou, C. M., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Thorsen, T., Quist, H., Matese, J. C., Brown, P. O., Botstein, D., LÃ¸nning, P. E., & BÃ¸rresen-Dale, A.-L. (2001). Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proceedings of the National Academy of Sciences, 98(19), 10869â10874.

Authors 17

Therese Sørlie (first)
Charles M. Perou (additional)
Robert Tibshirani (additional)
Turid Aas (additional)
Stephanie Geisler (additional)
Hilde Johnsen (additional)
Trevor Hastie (additional)
Michael B. Eisen (additional)
Matt van de Rijn (additional)
Stefanie S. Jeffrey (additional)
Thor Thorsen (additional)
Hanne Quist (additional)
John C. Matese (additional)
Patrick O. Brown (additional)
David Botstein (additional)
Per Eystein Lønning (additional)
Anne-Lise Børresen-Dale (additional)

References 20 Referenced 8,558

10.1002/1097-0142(19930315)71:6 <2141::AID-CNCR2820711603>3.0.CO;2-F
10.1111/j.1365-2559.1991.tb00229.x
10.1016/S0009-8981(97)06542-X
10.1002/1097-0142(19860315)57:6<1171::AID-CNCR2820570618>3.0.CO;2-X
10.1038/sj.bjc.6690048
10.1126/science.2470152
10.1002/gcc.2870140113
10.1038/nm1095-1029
10.1016/0277-5379(88)90068-5
10.1038/bjc.1983.101
10.1038/35000501
10.1056/NEJM200102223440801
10.1126/science.286.5439.531
10.1038/35021093
S Geisler, P E Lonning, T Aas, H Johnsen, O Fluge, D F Haugan, J R Lillehaug, L A Akslen, A-L Børresen-Dale Cancer Res 61, 2505–2512 (2001). / Cancer Res by Geisler S (2001)
10.1073/pnas.091062498
10.1073/pnas.95.25.14863
10.1038/nm0796-811
E M Berns, J A Foekens, R Vossen, M P Look, P Devilee, S C Henzen-Logmans, I L van Staveren, W L van Putten, M Inganas, M E Meijer-van Gelder, et al. Cancer Res 60, 2155–2162 (2000). / Cancer Res by Berns E M (2000)
10.1002/(SICI)1096-9896(199605)179:1<31::AID-PATH523>3.0.CO;2-O

Dates

Type	When
Created	23 years ago (July 26, 2002, 10:44 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 5:38 a.m.)
Indexed	15 hours, 34 minutes ago (Aug. 23, 2025, 12:58 a.m.)
Issued	23 years, 11 months ago (Sept. 11, 2001)
Published	23 years, 11 months ago (Sept. 11, 2001)
Published Online	23 years, 11 months ago (Sept. 11, 2001)
Published Print	23 years, 11 months ago (Sept. 11, 2001)

Funders 0

None

BibTeX

@article{S_rlie_2001, title={Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.191367098}, DOI={10.1073/pnas.191367098}, number={19}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Sørlie, Therese and Perou, Charles M. and Tibshirani, Robert and Aas, Turid and Geisler, Stephanie and Johnsen, Hilde and Hastie, Trevor and Eisen, Michael B. and van de Rijn, Matt and Jeffrey, Stefanie S. and Thorsen, Thor and Quist, Hanne and Matese, John C. and Brown, Patrick O. and Botstein, David and Lønning, Per Eystein and Børresen-Dale, Anne-Lise}, year={2001}, month=sep, pages={10869–10874} }

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