DOI: 10.1073/pnas.191352298. Calcium regulation of neuronal gene expression

Calcium regulation of neuronal gene expression

10.1073/pnas.191352298

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Plasticity is a remarkable feature of the brain, allowing neuronal structure and function to accommodate to patterns of electrical activity. One component of these long-term changes is the activity-driven induction of new gene expression, which is required for both the long-lasting long-term potentiation of synaptic transmission associated with learning and memory, and the activitydependent survival events that help to shape and wire the brain during development. We have characterized molecular mechanisms by which neuronal membrane depolarization and subsequent calcium influx into the cytoplasm lead to the induction of new gene transcription. We have identified three points within this cascade of events where the specificity of genes induced by different types of stimuli can be regulated. By using the induction of the gene that encodes brain-derived neurotrophic factor (BDNF) as a model, we have found that the ability of a calcium influx to induce transcription of this gene is regulated by the route of calcium entry into the cell, by the pattern of phosphorylation induced on the transcription factor cAMP-response element (CRE) binding protein (CREB), and by the complement of active transcription factors recruited to the BDNF promoter. These results refine and expand the working model of activity-induced gene induction in the brain, and help to explain how different types of neuronal stimuli can activate distinct transcriptional responses.

Bibliography

West, A. E., Chen, W. G., Dalva, M. B., Dolmetsch, R. E., Kornhauser, J. M., Shaywitz, A. J., Takasu, M. A., Tao, X., & Greenberg, M. E. (2001). Calcium regulation of neuronal gene expression. Proceedings of the National Academy of Sciences, 98(20), 11024â11031.

Authors 9

Anne E. West (first)
Wen G. Chen (additional)
Matthew B. Dalva (additional)
Ricardo E. Dolmetsch (additional)
Jon M. Kornhauser (additional)
Adam J. Shaywitz (additional)
Mari A. Takasu (additional)
Xu Tao (additional)
Michael E. Greenberg (additional)

References 80 Referenced 856

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:37 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 5:29 a.m.)
Indexed	1 day, 15 hours ago (Sept. 4, 2025, 10:05 a.m.)
Issued	23 years, 11 months ago (Sept. 25, 2001)
Published	23 years, 11 months ago (Sept. 25, 2001)
Published Online	23 years, 11 months ago (Sept. 25, 2001)
Published Print	23 years, 11 months ago (Sept. 25, 2001)

Funders 0

None

BibTeX

@article{West_2001, title={Calcium regulation of neuronal gene expression}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.191352298}, DOI={10.1073/pnas.191352298}, number={20}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={West, Anne E. and Chen, Wen G. and Dalva, Matthew B. and Dolmetsch, Ricardo E. and Kornhauser, Jon M. and Shaywitz, Adam J. and Takasu, Mari A. and Tao, Xu and Greenberg, Michael E.}, year={2001}, month=sep, pages={11024–11031} }

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  "abstract": "<jats:p>\n            Plasticity is a remarkable feature of the brain, allowing neuronal\n structure and function to accommodate to patterns of electrical\n activity. One component of these long-term changes is the\n activity-driven induction of new gene expression, which is required for\n both the long-lasting long-term potentiation of synaptic transmission\n associated with learning and memory, and the activitydependent\n survival events that help to shape and wire the brain during\n development. We have characterized molecular mechanisms by which\n neuronal membrane depolarization and subsequent calcium influx into the\n cytoplasm lead to the induction of new gene transcription. We have\n identified three points within this cascade of events where the\n specificity of genes induced by different types of stimuli can be\n regulated. By using the induction of the gene that encodes\n brain-derived neurotrophic factor (BDNF) as a model, we have found that\n the ability of a calcium influx to induce transcription of this gene is\n regulated by the route of calcium entry into the cell, by the pattern\n of phosphorylation induced on the transcription factor cAMP-response\n element (CRE) binding protein (CREB), and by the complement of active\n transcription factors recruited to the\n            <jats:italic>BDNF</jats:italic>\n            promoter.\n These results refine and expand the working model of activity-induced\n gene induction in the brain, and help to explain how different types of\n neuronal stimuli can activate distinct transcriptional responses.\n          </jats:p>",
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    "10.1073/pnas.191352298"
  ],
  "URL": "http://dx.doi.org/10.1073/pnas.191352298",
  "relation": {},
  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        2001,
        9,
        25
      ]
    ]
  },
  "assertion": [
    {
      "value": "2001-09-25",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}