DOI: 10.1073/pnas.1735528100. Histone sumoylation is associated with transcriptional repression

Histone sumoylation is associated with transcriptional repression

10.1073/pnas.1735528100

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Histone proteins are subject to modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, and ADP ribosylation, some of which are known to play important roles in the regulation of chromatin structure and function. Here we report that histone H4 is modified by small ubiquitin-related modifier (SUMO) family proteins both in vivo and in vitro . H4 binds to the SUMO-conjugating enzyme (E2), UBC9, and can be sumoylated in an E1 (SUMO-activating enzyme)- and E2-dependent manner. We present evidence suggesting that histone sumoylation mediates gene silencing through recruitment of histone deacetylase and heterochromatin protein 1.

Bibliography

Shiio, Y., & Eisenman, R. N. (2003). Histone sumoylation is associated with transcriptional repression. Proceedings of the National Academy of Sciences, 100(23), 13225â13230.

Authors 2

Yuzuru Shiio (first)
Robert N. Eisenman (additional)

References 40 Referenced 534

Dates

Type	When
Created	21 years, 9 months ago (Nov. 16, 2003, 3:42 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 3:40 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 7, 2025, 4:53 a.m.)
Issued	21 years, 10 months ago (Oct. 24, 2003)
Published	21 years, 10 months ago (Oct. 24, 2003)
Published Online	21 years, 10 months ago (Oct. 24, 2003)
Published Print	21 years, 9 months ago (Nov. 11, 2003)

Funders 0

None

BibTeX

@article{Shiio_2003, title={Histone sumoylation is associated with transcriptional repression}, volume={100}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.1735528100}, DOI={10.1073/pnas.1735528100}, number={23}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Shiio, Yuzuru and Eisenman, Robert N.}, year={2003}, month=oct, pages={13225–13230} }

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