DOI: 10.1073/pnas.152439199. Cytochrome <i>c</i> folding pathway: Kinetic native-state hydrogen exchange [Penn]

Cytochrome c folding pathway: Kinetic native-state hydrogen exchange

10.1073/pnas.152439199

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Native-state hydrogen exchange experiments under EX1 conditions can distinguish partially unfolded intermediates by their formation rates and identify the amide hydrogens exposed and protected in each. Results obtained define a cytochrome c intermediate seen only poorly before and place it early on the major unfolding pathway. Four distinct unfolding steps are found to be kinetically ordered in the same pathway sequence inferred before.

Bibliography

Hoang, L., BÃ©dard, S., Krishna, M. M. G., Lin, Y., & Englander, S. W. (2002). Cytochrome c folding pathway: Kinetic native-state hydrogen exchange. Proceedings of the National Academy of Sciences, 99(19), 12173â12178.

Authors 5

Linh Hoang (first)
Sabrina Bédard (additional)
Mallela M. G. Krishna (additional)
Yan Lin (additional)
S. Walter Englander (additional)

References 41 Referenced 105

10.1126/science.7618079
10.1002/(SICI)1097-0134(199602)24:2<145::AID-PROT1>3.0.CO;2-I
10.1038/nsb0996-782
10.1073/pnas.94.21.11329
10.1021/bi980894o
10.1002/(SICI)1097-0134(19980215)30:3<295::AID-PROT9>3.0.CO;2-J
10.1038/14956
10.1002/pro.5560060517
10.1038/1810
10.1016/S1359-0278(96)00038-7
10.1016/S0968-0004(97)01087-6
10.1002/anie.196400011
10.1016/0003-9861(57)90478-2
10.1021/bi00752a003
10.1002/prot.340170111
10.1002/prot.340170110
Linderstrøm-Lang K. U. (1955) Chem. Soc. Spec. Publ.2,1-20. / Chem. Soc. Spec. Publ. by Linderstrøm-Lang K. U. (1955)
10.1016/S0065-3233(08)60129-1
10.1021/bi00088a013
10.1126/science.8235609
10.1002/prot.340200103
10.1021/bi00193a001
10.1002/pro.5560070323
10.1006/jmbi.2000.3536
10.1038/nsb768
10.1073/pnas.92.7.2657
10.1073/pnas.93.5.1982
10.1016/0301-4622(95)00142-5
Wilson M. T. & Greenwood C. (1996) in Cytochrome c: A Multidisciplinary Approach eds. Scott R. A. & Mauk A. G. (University Science Books Sausolito CA) pp. 611–634.
10.1042/bj1770641
10.1111/j.1432-1033.1971.tb01508.x
10.1038/86208
Kalodimos C. G., Boelens, R. & Kaptein, R. (2002) Nat. Struct. Biol.9,193-197.11850636 / Nat. Struct. Biol. by Kalodimos C. G. (2002)
10.1023/A:1008316430724
10.1038/335700a0
10.1073/pnas.96.2.477
10.1038/nsb794
10.1073/pnas.98.1.105
10.1002/(SICI)1097-0134(199604)24:4<413::AID-PROT1>3.0.CO;2-F
10.1006/jmbi.1998.1645
10.1021/bi982078m

Dates

Type	When
Created	22 years, 11 months ago (Sept. 17, 2002, 12:40 p.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:57 a.m.)
Indexed	1 year, 1 month ago (July 24, 2024, 3:12 a.m.)
Issued	23 years ago (Aug. 26, 2002)
Published	23 years ago (Aug. 26, 2002)
Published Online	23 years ago (Aug. 26, 2002)
Published Print	22 years, 11 months ago (Sept. 17, 2002)

Funders 0

None

BibTeX

@article{Hoang_2002, title={Cytochrome c folding pathway: Kinetic native-state hydrogen exchange}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.152439199}, DOI={10.1073/pnas.152439199}, number={19}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hoang, Linh and Bédard, Sabrina and Krishna, Mallela M. G. and Lin, Yan and Englander, S. Walter}, year={2002}, month=aug, pages={12173–12178} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        7,
        24
      ]
    ],
    "date-time": "2024-07-24T07:12:15Z",
    "timestamp": 1721805135650
  },
  "reference-count": 41,
  "publisher": "Proceedings of the National Academy of Sciences",
  "issue": "19",
  "content-domain": {
    "domain": [
      "www.pnas.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2002,
        9,
        17
      ]
    ]
  },
  "abstract": "<jats:p>\n            Native-state hydrogen exchange experiments under EX1 conditions can distinguish partially unfolded intermediates by their formation rates and identify the amide hydrogens exposed and protected in each. Results obtained define a cytochrome\n            <jats:italic>c</jats:italic>\n            intermediate seen only poorly before and place it early on the major unfolding pathway. Four distinct unfolding steps are found to be kinetically ordered in the same pathway sequence inferred before.\n          </jats:p>",
  "DOI": "10.1073/pnas.152439199",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        9,
        17
      ]
    ],
    "date-time": "2002-09-17T16:40:55Z",
    "timestamp": 1032280855000
  },
  "page": "12173-12178",
  "update-policy": "http://dx.doi.org/10.1073/pnas.cm10313",
  "source": "Crossref",
  "is-referenced-by-count": 105,
  "title": "Cytochrome\n            <i>c</i>\n            folding pathway: Kinetic native-state hydrogen exchange",
  "prefix": "10.1073",
  "volume": "99",
  "author": [
    {
      "given": "Linh",
      "family": "Hoang",
      "sequence": "first",
      "affiliation": [
        {
          "name": "The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6059"
        }
      ]
    },
    {
      "given": "Sabrina",
      "family": "B\u00e9dard",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6059"
        }
      ]
    },
    {
      "given": "Mallela M. G.",
      "family": "Krishna",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6059"
        }
      ]
    },
    {
      "given": "Yan",
      "family": "Lin",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6059"
        }
      ]
    },
    {
      "given": "S. Walter",
      "family": "Englander",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "The Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6059"
        }
      ]
    }
  ],
  "member": "341",
  "published-online": {
    "date-parts": [
      [
        2002,
        8,
        26
      ]
    ]
  },
  "reference": [
    {
      "key": "e_1_3_3_1_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7618079"
    },
    {
      "key": "e_1_3_3_2_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-0134(199602)24:2<145::AID-PROT1>3.0.CO;2-I"
    },
    {
      "key": "e_1_3_3_3_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nsb0996-782"
    },
    {
      "key": "e_1_3_3_4_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.21.11329"
    },
    {
      "key": "e_1_3_3_5_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi980894o"
    },
    {
      "key": "e_1_3_3_6_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-0134(19980215)30:3<295::AID-PROT9>3.0.CO;2-J"
    },
    {
      "key": "e_1_3_3_7_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/14956"
    },
    {
      "key": "e_1_3_3_8_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/pro.5560060517"
    },
    {
      "key": "e_1_3_3_9_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/1810"
    },
    {
      "key": "e_1_3_3_10_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1359-0278(96)00038-7"
    },
    {
      "key": "e_1_3_3_11_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0968-0004(97)01087-6"
    },
    {
      "key": "e_1_3_3_12_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/anie.196400011"
    },
    {
      "key": "e_1_3_3_13_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0003-9861(57)90478-2"
    },
    {
      "key": "e_1_3_3_14_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00752a003"
    },
    {
      "key": "e_1_3_3_15_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.340170111"
    },
    {
      "key": "e_1_3_3_16_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.340170110"
    },
    {
      "key": "e_1_3_3_17_2",
      "first-page": "1",
      "volume": "2",
      "author": "Linderstr\u00f8m-Lang K. U.",
      "year": "1955",
      "unstructured": "Linderstr\u00f8m-Lang K. U. (1955) Chem. Soc. Spec. Publ.2,1-20.",
      "journal-title": "Chem. Soc. Spec. Publ."
    },
    {
      "key": "e_1_3_3_18_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0065-3233(08)60129-1"
    },
    {
      "key": "e_1_3_3_19_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00088a013"
    },
    {
      "key": "e_1_3_3_20_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.8235609"
    },
    {
      "key": "e_1_3_3_21_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/prot.340200103"
    },
    {
      "key": "e_1_3_3_22_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00193a001"
    },
    {
      "key": "e_1_3_3_23_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/pro.5560070323"
    },
    {
      "key": "e_1_3_3_24_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmbi.2000.3536"
    },
    {
      "key": "e_1_3_3_25_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nsb768"
    },
    {
      "key": "e_1_3_3_26_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.92.7.2657"
    },
    {
      "key": "e_1_3_3_27_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.5.1982"
    },
    {
      "key": "e_1_3_3_28_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0301-4622(95)00142-5"
    },
    {
      "key": "e_1_3_3_29_2",
      "unstructured": "Wilson M. T. & Greenwood C. (1996) in Cytochrome c: A Multidisciplinary Approach eds. Scott R. A. & Mauk A. G. (University Science Books Sausolito CA) pp. 611\u2013634."
    },
    {
      "key": "e_1_3_3_30_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj1770641"
    },
    {
      "key": "e_1_3_3_31_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1971.tb01508.x"
    },
    {
      "key": "e_1_3_3_32_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/86208"
    },
    {
      "key": "e_1_3_3_33_2",
      "first-page": "193",
      "volume": "9",
      "author": "Kalodimos C. G.",
      "year": "2002",
      "unstructured": "Kalodimos C. G., Boelens, R. & Kaptein, R. (2002) Nat. Struct. Biol.9,193-197.11850636",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "e_1_3_3_34_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1023/A:1008316430724"
    },
    {
      "key": "e_1_3_3_35_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/335700a0"
    },
    {
      "key": "e_1_3_3_36_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.96.2.477"
    },
    {
      "key": "e_1_3_3_37_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/nsb794"
    },
    {
      "key": "e_1_3_3_38_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.98.1.105"
    },
    {
      "key": "e_1_3_3_39_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-0134(199604)24:4<413::AID-PROT1>3.0.CO;2-F"
    },
    {
      "key": "e_1_3_3_40_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmbi.1998.1645"
    },
    {
      "key": "e_1_3_3_41_2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi982078m"
    }
  ],
  "container-title": "Proceedings of the National Academy of Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://pnas.org/doi/pdf/10.1073/pnas.152439199",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        4,
        13
      ]
    ],
    "date-time": "2022-04-13T04:57:02Z",
    "timestamp": 1649825822000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://pnas.org/doi/full/10.1073/pnas.152439199"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2002,
        8,
        26
      ]
    ]
  },
  "references-count": 41,
  "journal-issue": {
    "issue": "19",
    "published-print": {
      "date-parts": [
        [
          2002,
          9,
          17
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1073/pnas.152439199"
  ],
  "URL": "http://dx.doi.org/10.1073/pnas.152439199",
  "relation": {},
  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        2002,
        8,
        26
      ]
    ]
  },
  "assertion": [
    {
      "value": "2002-07-24",
      "order": 1,
      "name": "accepted",
      "label": "Accepted",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2002-08-26",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}