DOI: 10.1073/pnas.150240097. Inhibition of MHC class I-restricted antigen presentation by γ2-herpesviruses

Inhibition of MHC class I-restricted antigen presentation by γ2-herpesviruses

10.1073/pnas.150240097

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The γ-herpesviruses, in contrast to the α- and β-herpesviruses, are not known to inhibit antigen presentation to CD8 + cytotoxic T lymphocytes (CTLs) during lytic cycle replication. However, murine γ-herpesvirus 68 causes a chronic lytic infection in CD4 + T cell-deficient mice despite the persistence of a substantial CTL response, suggesting that CTL evasion occurs. Here we show that, distinct from host protein synthesis shutoff, γ-herpesvirus 68 down-regulates surface MHC class I expression on lytically infected fibroblasts and inhibits their recognition by antigen-specific CTLs. The viral K3 gene, encoding a zinc-finger-containing protein, dramatically reduced the half-life of nascent class I molecules and the level of surface MHC class I expression and was by itself sufficient to block antigen presentation. The homologous K3 and K5 genes of the related Kaposi's sarcoma-associated virus also inhibited antigen presentation and decreased cell surface expression of HLA class I antigens. Thus it appears that an immune evasion strategy shared by at least two γ-herpesviruses allows continued lytic infection in the face of strong CTL immunity.

Bibliography

Stevenson, P. G., Efstathiou, S., Doherty, P. C., & Lehner, P. J. (2000). Inhibition of MHC class I-restricted antigen presentation by Î³2-herpesviruses. Proceedings of the National Academy of Sciences, 97(15), 8455â8460.

Authors 4

Philip G. Stevenson (first)
Stacey Efstathiou (additional)
Peter C. Doherty (additional)
Paul J. Lehner (additional)

References 35 Referenced 185

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:35 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:04 a.m.)
Indexed	4 months, 3 weeks ago (April 10, 2025, 7:28 a.m.)
Issued	25 years, 1 month ago (July 11, 2000)
Published	25 years, 1 month ago (July 11, 2000)
Published Online	25 years, 1 month ago (July 11, 2000)
Published Print	25 years, 1 month ago (July 18, 2000)

Funders 0

None

BibTeX

@article{Stevenson_2000, title={Inhibition of MHC class I-restricted antigen presentation by γ2-herpesviruses}, volume={97}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.150240097}, DOI={10.1073/pnas.150240097}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Stevenson, Philip G. and Efstathiou, Stacey and Doherty, Peter C. and Lehner, Paul J.}, year={2000}, month=jul, pages={8455–8460} }

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