DOI: 10.1073/pnas.141224998. Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway

Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway

10.1073/pnas.141224998

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Rearrangements of the high mobility group protein I-C (HMGI-C) gene, consisting in the loss of the carboxyl-terminal tail, have been frequently detected in benign human tumors of mesenchymal origin. We have previously demonstrated that transgenic (TG) mice carrying a truncated HMGI-C construct (HMGI-C/T) exhibit a giant phenotype together with a predominantly abdominal/pelvic lipomatosis. Here, we report that HMGI-C/T TG mice develop natural killer (NK)-T/NK cell lymphomas starting from 12 months of age. We found an increased expression of IL-2 and IL-15 proteins and their receptors in these lymphomas, and we demonstrate that HMGI-C/T protein positively regulates their expression in vitro . Therefore, the HMGI-C/T-mediated chronic stimulation of the IL-2/IL-15 pathway could be responsible for the onset of NK-T/NK cell lymphomas in HMGI-C/T TG mice.

Bibliography

Baldassarre, G., Fedele, M., Battista, S., Vecchione, A., Klein-Szanto, A. J. P., Santoro, M., Waldmann, T. A., Azimi, N., Croce, C. M., & Fusco, A. (2001). Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. Proceedings of the National Academy of Sciences, 98(14), 7970â7975.

Authors 10

Gustavo Baldassarre (first)
Monica Fedele (additional)
Sabrina Battista (additional)
Andrea Vecchione (additional)
Andres J. P. Klein-Szanto (additional)
Massimo Santoro (additional)
Thomas A. Waldmann (additional)
Nazli Azimi (additional)
Carlo M. Croce (additional)
Alfredo Fusco (additional)

References 40 Referenced 78

10.1093/nar/19.24.6793
G Goodwin, M Bustin Architecture of Eukaryotic Genes, ed G Kahl (VCH, Weinheim, Germany), pp. 187–205 (1988). / Architecture of Eukaryotic Genes by Goodwin G (1988)
10.1016/0092-8674(92)90554-P
10.1016/0168-9525(94)90232-1
10.1093/nar/26.6.1433
10.1093/nar/21.24.5694
10.1128/MCB.15.3.1786
10.1016/0092-8674(95)90052-7
10.1038/ng0895-436
10.1038/sj.onc.1201952
S Battista, V Fidanza, M Fedele, A J Klein-Szanto, E Outwater, H Brunner, M Santoro, C M Croce, A Fusco Cancer Res 59, 4793–4797 (1999). / Cancer Res by Battista S (1999)
10.1074/jbc.272.46.28853
10.1128/JVI.74.16.7338-7348.2000
10.1016/S1074-7613(00)80503-8
10.1159/000212636
10.1084/jem.183.1.187
10.1111/j.1600-065X.1998.tb01229.x
10.1016/S0960-9822(06)00208-9
10.1016/S0161-5890(00)00018-3
10.4049/jimmunol.164.6.3157
10.1084/jem.191.5.753
10.1084/jem.185.3.499
10.1016/S1074-7613(00)80664-0
10.1084/jem.191.5.771
10.1016/S0171-2985(98)80060-0
10.1016/S0301-472X(99)00042-9
10.1182/blood.V84.5.1361.1361
10.1080/00313029800169136
10.1084/jem.180.4.1395
10.1182/blood.V89.11.4005
10.1073/pnas.95.7.3810
10.1084/jem.191.1.157
10.1146/annurev.immunol.17.1.19
10.1038/35636
10.1016/0092-8674(93)80067-O
10.1016/1074-7613(95)90180-9
10.1038/nm1097-1124
10.1172/JCI119258
10.1073/pnas.200363097
10.1084/jem.193.2.219

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:34 a.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 11:27 p.m.)
Indexed	1 year, 1 month ago (July 20, 2024, 6:14 p.m.)
Issued	24 years, 2 months ago (June 26, 2001)
Published	24 years, 2 months ago (June 26, 2001)
Published Online	24 years, 2 months ago (June 26, 2001)
Published Print	24 years, 2 months ago (July 3, 2001)

Funders 0

None

BibTeX

@article{Baldassarre_2001, title={Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.141224998}, DOI={10.1073/pnas.141224998}, number={14}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Baldassarre, Gustavo and Fedele, Monica and Battista, Sabrina and Vecchione, Andrea and Klein-Szanto, Andres J. P. and Santoro, Massimo and Waldmann, Thomas A. and Azimi, Nazli and Croce, Carlo M. and Fusco, Alfredo}, year={2001}, month=jun, pages={7970–7975} }

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