DOI: 10.1073/pnas.140208197. A male germ cell tumor-susceptibility-determining locus, <i>pgct1</i> , identified on murine chromosome 13

A male germ cell tumor-susceptibility-determining locus, pgct1 , identified on murine chromosome 13

10.1073/pnas.140208197

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Inbred 129 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes. The inherent genetic defects that underlie male GCT susceptibility in the 129 mouse strain are unknown. GCT incidence is increased in 129 strain males that lack functional p53 protein, and we have used this finding to facilitate the generation of panels of GCT-bearing intercross and backcross mice for genetic mapping analysis. A 129 strain locus, designated pgct1 , that segregates with the male GCT phenotype has been identified on chromosome 13 near D13Mit188 . This region of murine chromosome 13 may be syntenic to a portion of human chromosome 5q that is implicated in male GCT susceptibility in humans.

Bibliography

Muller, A. J., Teresky, A. K., & Levine, A. J. (2000). A male germ cell tumor-susceptibility-determining locus, pgct1 , identified on murine chromosome 13. Proceedings of the National Academy of Sciences, 97(15), 8421â8426.

Authors 3

Alexander J. Muller (first)
Angelika K. Teresky (additional)
Arnold J. Levine (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:35 a.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 11:06 p.m.)
Indexed	1 year, 10 months ago (Oct. 18, 2023, 7:17 p.m.)
Issued	25 years, 1 month ago (July 11, 2000)
Published	25 years, 1 month ago (July 11, 2000)
Published Online	25 years, 1 month ago (July 11, 2000)
Published Print	25 years, 1 month ago (July 18, 2000)

Funders 0

None

BibTeX

@article{Muller_2000, title={A male germ cell tumor-susceptibility-determining locus, pgct1 , identified on murine chromosome 13}, volume={97}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.140208197}, DOI={10.1073/pnas.140208197}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Muller, Alexander J. and Teresky, Angelika K. and Levine, Arnold J.}, year={2000}, month=jul, pages={8421–8426} }

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