DOI: 10.1073/pnas.1323016111. Spatial constraints control cell proliferation in tissues

Spatial constraints control cell proliferation in tissues

10.1073/pnas.1323016111

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Significance Spatiotemporal coordination of cell growth underlies tissue development and disease. Mechanical feedback between cells has been proposed as a regulatory mechanism for growth control both in vivo and in cultured cells undergoing contact inhibition of proliferation. Evidence beyond theoretical and correlative observations falls short. In this study, we probe the impact of mechanical tissue perturbations on cell cycle progression by monitoring cell cycle dynamics of cells in tissues subject to acute changes in boundary conditions, as well as tissue stretching and compression. Taken together, we conclude that the ability of tissues to support cell cycle progression adapts to the available space through a memory-free control mechanism, which may coordinate proliferation patterns to maintain tissue homeostasis.

Bibliography

Streichan, S. J., Hoerner, C. R., Schneidt, T., Holzer, D., & Hufnagel, L. (2014). Spatial constraints control cell proliferation in tissues. Proceedings of the National Academy of Sciences, 111(15), 5586â5591.

Authors 5

Sebastian J. Streichan (first)
Christian R. Hoerner (additional)
Tatjana Schneidt (additional)
Daniela Holzer (additional)
Lars Hufnagel (additional)

References 50 Referenced 240

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Dates

Type	When
Created	11 years, 4 months ago (April 1, 2014, 2:13 a.m.)
Deposited	3 years, 4 months ago (April 16, 2022, 7:26 a.m.)
Indexed	3 weeks, 3 days ago (July 28, 2025, 5:38 p.m.)
Issued	11 years, 4 months ago (March 31, 2014)
Published	11 years, 4 months ago (March 31, 2014)
Published Online	11 years, 4 months ago (March 31, 2014)
Published Print	11 years, 4 months ago (April 15, 2014)

Funders 0

None

BibTeX

@article{Streichan_2014, title={Spatial constraints control cell proliferation in tissues}, volume={111}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.1323016111}, DOI={10.1073/pnas.1323016111}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Streichan, Sebastian J. and Hoerner, Christian R. and Schneidt, Tatjana and Holzer, Daniela and Hufnagel, Lars}, year={2014}, month=mar, pages={5586–5591} }

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