DOI: 10.1073/pnas.121172298. Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading

Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading

10.1073/pnas.121172298

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In the context of cell signaling, kinetic proofreading was introduced to explain how cells can discriminate among ligands based on a kinetic parameter, the ligand-receptor dissociation rate constant. In the kinetic proofreading model of cell signaling, responses occur only when a bound receptor undergoes a complete series of modifications. If the ligand dissociates prematurely, the receptor returns to its basal state and signaling is frustrated. We extend the model to deal with systems where aggregation of receptors is essential to signal transduction, and present a version of the model for systems where signaling depends on an extrinsic kinase. We also investigate the kinetics of signaling molecules, “messengers,” that are generated by aggregated receptors but do not remain associated with the receptor complex. We show that the extended model predicts modes of signaling that exhibit kinetic discrimination for some range of parameters but for other parameter values show little or no discrimination and thus escape kinetic proofreading. We compare model predictions with experimental data.

Bibliography

Hlavacek, W. S., Redondo, A., Metzger, H., Wofsy, C., & Goldstein, B. (2001). Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. Proceedings of the National Academy of Sciences, 98(13), 7295â7300.

Authors 5

William S. Hlavacek (first)
Antonio Redondo (additional)
Henry Metzger (additional)
Carla Wofsy (additional)
Byron Goldstein (additional)

References 29 Referenced 51

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:45 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:34 a.m.)
Indexed	1 year, 1 month ago (Aug. 3, 2024, 4:20 p.m.)
Issued	24 years, 2 months ago (June 5, 2001)
Published	24 years, 2 months ago (June 5, 2001)
Published Online	24 years, 2 months ago (June 5, 2001)
Published Print	24 years, 2 months ago (June 19, 2001)

Funders 0

None

BibTeX

@article{Hlavacek_2001, title={Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.121172298}, DOI={10.1073/pnas.121172298}, number={13}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hlavacek, William S. and Redondo, Antonio and Metzger, Henry and Wofsy, Carla and Goldstein, Byron}, year={2001}, month=jun, pages={7295–7300} }

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