DOI: 10.1073/pnas.121145898. The target of rapamycin (TOR) proteins

10.1073/pnas.121145898

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient quality and quantity. The TOR proteins regulate (i) the initiation and elongation phases of translation, (ii) ribosome biosynthesis, (iii) amino acid import, (iv) the transcription of numerous enzymes involved in multiple metabolic pathways, and (v) autophagy. Intriguingly, recent studies have also suggested that TOR signaling plays a critical role in brain development, learning, and memory formation.

Bibliography

Raught, B., Gingras, A.-C., & Sonenberg, N. (2001). The target of rapamycin (TOR) proteins. Proceedings of the National Academy of Sciences, 98(13), 7037â7044.

Authors 3

Brian Raught (first)
Anne-Claude Gingras (additional)
Nahum Sonenberg (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:45 a.m.)
Deposited	2 years, 4 months ago (April 22, 2023, 8:34 a.m.)
Indexed	3 days, 10 hours ago (Aug. 29, 2025, 5:56 a.m.)
Issued	24 years, 2 months ago (June 19, 2001)
Published	24 years, 2 months ago (June 19, 2001)
Published Online	24 years, 2 months ago (June 19, 2001)
Published Print	24 years, 2 months ago (June 19, 2001)

Funders 0

None

BibTeX

@article{Raught_2001, title={The target of rapamycin (TOR) proteins}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.121145898}, DOI={10.1073/pnas.121145898}, number={13}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Raught, Brian and Gingras, Anne-Claude and Sonenberg, Nahum}, year={2001}, month=jun, pages={7037–7044} }

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