DOI: 10.1073/pnas.102157499. Inositol hexakisphosphate promotes dynamin I- mediated endocytosis

Inositol hexakisphosphate promotes dynamin I- mediated endocytosis

10.1073/pnas.102157499

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Membrane homeostasis is maintained by exocytosis and endocytosis. The molecular mechanisms regulating the interplay between these two processes are not clear. Inositol hexakisphosphate (InsP 6 ) is under metabolic control and serves as a signal in the pancreatic β cell stimulus-secretion coupling by increasing Ca 2+ -channel activity and insulin exocytosis. We now show that InsP 6 also promotes dynamin I-mediated endocytosis in the pancreatic β cell. This effect of InsP 6 depends on calcineurin-induced dephosphorylation and is accounted for by both activation of protein kinase C and inhibition of the phosphoinositide phosphatase synaptojanin and thereby formation of phosphatidylinositol 4,5-bisphosphate. In regulating both exocytosis and endocytosis, InsP 6 thus may have an essential integral role in membrane trafficking.

Bibliography

HÃ¸y, M., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Olsen, H. L., Bokvist, K., Leibiger, B., Leibiger, I. B., Zwiller, J., Berggren, P.-O., & Gromada, J. (2002). Inositol hexakisphosphate promotes dynamin I- mediated endocytosis. Proceedings of the National Academy of Sciences, 99(10), 6773â6777.

Authors 11

Marianne Høy (first)
Alexander M. Efanov (additional)
Alejandro M. Bertorello (additional)
Sergei V. Zaitsev (additional)
Hervør L. Olsen (additional)
Krister Bokvist (additional)
Barbara Leibiger (additional)
Ingo B. Leibiger (additional)
Jean Zwiller (additional)
Per-Olof Berggren (additional)
Jesper Gromada (additional)

References 21 Referenced 52

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:46 a.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 8 p.m.)
Indexed	1 week, 1 day ago (Aug. 22, 2025, 12:45 a.m.)
Issued	23 years, 3 months ago (May 14, 2002)
Published	23 years, 3 months ago (May 14, 2002)
Published Online	23 years, 3 months ago (May 14, 2002)
Published Print	23 years, 3 months ago (May 14, 2002)

Funders 0

None

BibTeX

@article{H_y_2002, title={Inositol hexakisphosphate promotes dynamin I- mediated endocytosis}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.102157499}, DOI={10.1073/pnas.102157499}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Høy, Marianne and Efanov, Alexander M. and Bertorello, Alejandro M. and Zaitsev, Sergei V. and Olsen, Hervør L. and Bokvist, Krister and Leibiger, Barbara and Leibiger, Ingo B. and Zwiller, Jean and Berggren, Per-Olof and Gromada, Jesper}, year={2002}, month=may, pages={6773–6777} }

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  "abstract": "<jats:p>\n            Membrane homeostasis is maintained by exocytosis and endocytosis. The molecular mechanisms regulating the interplay between these two processes are not clear. Inositol hexakisphosphate (InsP\n            <jats:sub>6</jats:sub>\n            ) is under metabolic control and serves as a signal in the pancreatic \u03b2 cell stimulus-secretion coupling by increasing Ca\n            <jats:sup>2+</jats:sup>\n            -channel activity and insulin exocytosis. We now show that InsP\n            <jats:sub>6</jats:sub>\n            also promotes dynamin I-mediated endocytosis in the pancreatic \u03b2 cell. This effect of InsP\n            <jats:sub>6</jats:sub>\n            depends on calcineurin-induced dephosphorylation and is accounted for by both activation of protein kinase C and inhibition of the phosphoinositide phosphatase synaptojanin and thereby formation of phosphatidylinositol 4,5-bisphosphate. In regulating both exocytosis and endocytosis, InsP\n            <jats:sub>6</jats:sub>\n            thus may have an essential integral role in membrane trafficking.\n          </jats:p>",
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