DOI: 10.1073/pnas.100113397. The yeast A kinases differentially regulate iron uptake and respiratory function

The yeast A kinases differentially regulate iron uptake and respiratory function

10.1073/pnas.100113397

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Yeast has three A kinase catalytic subunits, which have greater than 75% identity and are encoded by the TPK genes ( TPK1 , TPK2 , and TPK3 ) [Toda, T., Cameron, S., Sass, P., Zoller, M. & Wigler, M. (1987) Cell 50, 277–287]. Although they are redundant for viability, the three A kinases are not redundant for pseudohyphal growth [Robertson, L. S. & Fink, G. R. (1998) Proc. Natl. Acad. Sci. USA 95, 13783–13787; Pan, X. & Heitman, J. (1999) Mol. Cell. Biol. 19, 4874–4887]; Tpk2, but not Tpk1 or Tpk3, is required for pseudohyphal growth. Genome-wide transcriptional profiling has revealed unique signatures for each of the three A kinases leading to the identification of additional functional diversity among these proteins. Tpk2 negatively regulates genes involved in iron uptake and positively regulates genes involved in trehalose degradation and water homeostasis. Tpk1 is required for the derepression of branched chain amino acid biosynthesis genes that seem to have a second role in the maintenance of iron levels and DNA stability within mitochondria. The fact that TPK2 mutants grow better than wild types on nonfermentable carbon sources and on media deficient in iron supports the unique role of Tpk2 in respiratory growth and carbon source use.

Bibliography

Robertson, L. S., Causton, H. C., Young, R. A., & Fink, G. R. (2000). The yeast A kinases differentially regulate iron uptake and respiratory function. Proceedings of the National Academy of Sciences, 97(11), 5984â5988.

Authors 4

Laura S. Robertson (first)
Helen C. Causton (additional)
Richard A. Young (additional)
Gerald R. Fink (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:35 a.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 6:48 p.m.)
Indexed	4 months ago (April 29, 2025, 2:24 p.m.)
Issued	25 years, 3 months ago (May 16, 2000)
Published	25 years, 3 months ago (May 16, 2000)
Published Online	25 years, 3 months ago (May 16, 2000)
Published Print	25 years, 3 months ago (May 23, 2000)

Funders 0

None

BibTeX

@article{Robertson_2000, title={The yeast A kinases differentially regulate iron uptake and respiratory function}, volume={97}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.100113397}, DOI={10.1073/pnas.100113397}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Robertson, Laura S. and Causton, Helen C. and Young, Richard A. and Fink, Gerald R.}, year={2000}, month=may, pages={5984–5988} }

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