DOI: 10.1073/pnas.0915068107. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

10.1073/pnas.0915068107

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Centromere-associated protein-E (CENP-E) is a kinetochore-associated mitotic kinesin that is thought to function as the key receptor responsible for mitotic checkpoint signal transduction after interaction with spindle microtubules. We have identified GSK923295, an allosteric inhibitor of CENP-E kinesin motor ATPase activity, and mapped the inhibitor binding site to a region similar to that bound by loop-5 inhibitors of the kinesin KSP/Eg5. Unlike these KSP inhibitors, which block release of ADP and destabilize motor-microtubule interaction, GSK923295 inhibited release of inorganic phosphate and stabilized CENP-E motor domain interaction with microtubules. Inhibition of CENP-E motor activity in cultured cells and tumor xenografts caused failure of metaphase chromosome alignment and induced mitotic arrest, indicating that tight binding of CENP-E to microtubules is insufficient to satisfy the mitotic checkpoint. Consistent with genetic studies in mice suggesting that decreased CENP-E function can have a tumor-suppressive effect, inhibition of CENP-E induced tumor cell apoptosis and tumor regression.

Bibliography

Wood, K. W., Lad, L., Luo, L., Qian, X., Knight, S. D., Nevins, N., Brejc, K., Sutton, D., Gilmartin, A. G., Chua, P. R., Desai, R., Schauer, S. P., McNulty, D. E., Annan, R. S., Belmont, L. D., Garcia, C., Lee, Y., Diamond, M. A., Faucette, L. F., â¦ Jackson, J. R. (2010). Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proceedings of the National Academy of Sciences, 107(13), 5839â5844.

Authors 35

Kenneth W. Wood (first)
Latesh Lad (additional)
Lusong Luo (additional)
Xiangping Qian (additional)
Steven D. Knight (additional)
Neysa Nevins (additional)
Katjusa Brejc (additional)
David Sutton (additional)
Aidan G. Gilmartin (additional)
Penelope R. Chua (additional)
Radhika Desai (additional)
Stephen P. Schauer (additional)
Dean E. McNulty (additional)
Roland S. Annan (additional)
Lisa D. Belmont (additional)
Carlos Garcia (additional)
Yan Lee (additional)
Melody A. Diamond (additional)
Leo F. Faucette (additional)
Michele Giardiniere (additional)
ShuYun Zhang (additional)
Chiu-Mei Sun (additional)
Justin D. Vidal (additional)
Serge Lichtsteiner (additional)
William D. Cornwell (additional)
Joel D. Greshock (additional)
Richard F. Wooster (additional)
Jeffrey T. Finer (additional)
Robert A. Copeland (additional)
Pearl S. Huang (additional)
David J. Morgans (additional)
Dashyant Dhanak (additional)
Gustave Bergnes (additional)
Roman Sakowicz (additional)
Jeffrey R. Jackson (additional)

References 35 Referenced 213

10.1158/1078-0432.CCR-07-4443
10.1038/359536a0
10.1083/jcb.200802189
10.1083/jcb.143.1.49
10.1016/j.devcel.2008.11.004
10.1016/j.devcel.2008.11.005
10.1016/S1534-5807(01)00019-3
10.1083/jcb.200303167
10.1083/jcb.200505040
10.1038/35019518
10.1091/mbc.e03-07-0482
10.1126/science.1122142
10.1083/jcb.139.6.1373
10.1091/mbc.12.9.2776
10.1016/j.ccr.2006.12.003
10.1021/ml900018m
10.1021/bi9711184
10.1038/373671a0
10.1021/bi702061g
10.1016/j.jmb.2004.05.053
10.1093/emboj/20.11.2611
10.1126/science.288.5463.88
10.1016/S0092-8674(00)81562-7
10.1126/science.283.5405.1152
10.1158/1535-7163.MCT-08-0684
10.1016/j.ccr.2008.07.002
10.1016/j.bmcl.2005.02.055
G Bergnes, et al. Burger's Medicinal Chemistry, Drug Discovery and Development, ed D Rotella (Wiley, 7th Ed, New York / Burger's Medicinal Chemistry, Drug Discovery and Development by Bergnes G
10.1021/bi026716j
10.1083/jcb.146.5.941
10.1016/S0092-8674(03)00475-6
Z Hu, et al., Small molecular inhibitor of the centromere-associated protein E (CENP-E), GSK923295A inhibits cell growth in breast cancer cells. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research, ; 2009 Apr 18–22; Denver, CO. Philadelphia (PA): AACR; Abstract nr. 5572. (2009). / Proceedings of the 100th Annual Meeting of the American Association for Cancer Research / Small molecular inhibitor of the centromere-associated protein E (CENP-E), GSK923295A inhibits cell growth in breast cancer cells by Hu Z (2009)
10.1158/0008-5472.CAN-03-3839
10.1006/jmbi.1996.0897
10.1158/0008-5472.CAN-09-0945

Dates

Type	When
Created	15 years, 6 months ago (Feb. 18, 2010, 10:15 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 6:38 p.m.)
Indexed	2 weeks, 3 days ago (Aug. 19, 2025, 6 a.m.)
Issued	15 years, 6 months ago (Feb. 18, 2010)
Published	15 years, 6 months ago (Feb. 18, 2010)
Published Online	15 years, 6 months ago (Feb. 18, 2010)
Published Print	15 years, 5 months ago (March 30, 2010)

Funders 0

None

BibTeX

@article{Wood_2010, title={Antitumor activity of an allosteric inhibitor of centromere-associated protein-E}, volume={107}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0915068107}, DOI={10.1073/pnas.0915068107}, number={13}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Wood, Kenneth W. and Lad, Latesh and Luo, Lusong and Qian, Xiangping and Knight, Steven D. and Nevins, Neysa and Brejc, Katjusa and Sutton, David and Gilmartin, Aidan G. and Chua, Penelope R. and Desai, Radhika and Schauer, Stephen P. and McNulty, Dean E. and Annan, Roland S. and Belmont, Lisa D. and Garcia, Carlos and Lee, Yan and Diamond, Melody A. and Faucette, Leo F. and Giardiniere, Michele and Zhang, ShuYun and Sun, Chiu-Mei and Vidal, Justin D. and Lichtsteiner, Serge and Cornwell, William D. and Greshock, Joel D. and Wooster, Richard F. and Finer, Jeffrey T. and Copeland, Robert A. and Huang, Pearl S. and Morgans, David J. and Dhanak, Dashyant and Bergnes, Gustave and Sakowicz, Roman and Jackson, Jeffrey R.}, year={2010}, month=feb, pages={5839–5844} }

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