DOI: 10.1073/pnas.0907732106. A feeling for the numbers in biology

10.1073/pnas.0907732106

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Although the quantitative description of biological systems has been going on for centuries, recent advances in the measurement of phenomena ranging from metabolism to gene expression to signal transduction have resulted in a new emphasis on biological numeracy. This article describes the confluence of two different approaches to biological numbers. First, an impressive array of quantitative measurements make it possible to develop intuition about biological numbers ranging from how many gigatons of atmospheric carbon are fixed every year in the process of photosynthesis to the number of membrane transporters needed to provide sugars to rapidly dividingEscherichia colicells. As a result of the vast array of such quantitative data, the BioNumbers web site has recently been developed as a repository for biology by the numbers. Second, a complementary and powerful tradition of numerical estimates familiar from the physical sciences and canonized in the so-called “Fermi problems” calls for efforts to estimate key biological quantities on the basis of a few foundational facts and simple ideas from physics and chemistry. In this article, we describe these two approaches and illustrate their synergism in several particularly appealing case studies. These case studies reveal the impact that an emphasis on numbers can have on important biological questions.

Bibliography

Phillips, R., & Milo, R. (2009). A feeling for the numbers in biology. Proceedings of the National Academy of Sciences, 106(51), 21465â21471.

Authors 2

Rob Phillips (first)
Ron Milo (additional)

References 54 Referenced 112

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Dates

Type	When
Created	15 years, 8 months ago (Dec. 14, 2009, 10:19 p.m.)
Deposited	1 year, 5 months ago (March 18, 2024, 2:11 a.m.)
Indexed	1 week, 5 days ago (Aug. 19, 2025, 6:22 a.m.)
Issued	15 years, 8 months ago (Dec. 22, 2009)
Published	15 years, 8 months ago (Dec. 22, 2009)
Published Online	15 years, 8 months ago (Dec. 22, 2009)
Published Print	15 years, 8 months ago (Dec. 22, 2009)

Funders 0

None

BibTeX

@article{Phillips_2009, title={A feeling for the numbers in biology}, volume={106}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0907732106}, DOI={10.1073/pnas.0907732106}, number={51}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Phillips, Rob and Milo, Ron}, year={2009}, month=dec, pages={21465–21471} }

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  "ISSN": [
    "0027-8424",
    "1091-6490"
  ],
  "subject": [],
  "container-title-short": "Proc. Natl. Acad. Sci. U.S.A.",
  "published": {
    "date-parts": [
      [
        2009,
        12,
        22
      ]
    ]
  },
  "assertion": [
    {
      "value": "2009-07-14",
      "order": 0,
      "name": "received",
      "label": "Received",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    },
    {
      "value": "2009-12-22",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}