Abstract
The bioinorganic chemistry of iron is central to life processes. Organisms must recruit iron from their environment, control iron storage and trafficking within cells, assemble the complex, iron-containing redox cofactors of metalloproteins, and manage a myriad of biochemical transformations by those enzymes. The coordination chemistry and the variable oxidation states of iron provide the essential mechanistic machinery of this metabolism. Our current understanding of several aspects of the chemistry of iron in biology are discussed with an emphasis on the oxygen activation and transfer reactions mediated by heme and nonheme iron proteins and the interactions of amphiphilic iron siderophores with lipid membranes.
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Dates
Type | When |
---|---|
Created | 22 years, 5 months ago (April 1, 2003, 2:25 p.m.) |
Deposited | 3 years, 4 months ago (April 25, 2022, 10:03 p.m.) |
Indexed | 2 weeks, 1 day ago (Aug. 19, 2025, 6:32 a.m.) |
Issued | 22 years, 5 months ago (March 24, 2003) |
Published | 22 years, 5 months ago (March 24, 2003) |
Published Online | 22 years, 5 months ago (March 24, 2003) |
Published Print | 22 years, 5 months ago (April 1, 2003) |
@article{Groves_2003, title={The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies}, volume={100}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0830019100}, DOI={10.1073/pnas.0830019100}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Groves, John T.}, year={2003}, month=mar, pages={3569–3574} }