DOI: 10.1073/pnas.082099299. Diagnosis of multiple cancer types by shrunken centroids of gene expression

Diagnosis of multiple cancer types by shrunken centroids of gene expression

10.1073/pnas.082099299

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have devised an approach to cancer class prediction from gene expression profiling, based on an enhancement of the simple nearest prototype (centroid) classifier. We shrink the prototypes and hence obtain a classifier that is often more accurate than competing methods. Our method of “nearest shrunken centroids” identifies subsets of genes that best characterize each class. The technique is general and can be used in many other classification problems. To demonstrate its effectiveness, we show that the method was highly efficient in finding genes for classifying small round blue cell tumors and leukemias.

Bibliography

Tibshirani, R., Hastie, T., Narasimhan, B., & Chu, G. (2002). Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proceedings of the National Academy of Sciences, 99(10), 6567â6572.

Authors 4

Robert Tibshirani (first)
Trevor Hastie (additional)
Balasubramanian Narasimhan (additional)
Gilbert Chu (additional)

References 18 Referenced 2,141

10.1126/science.286.5439.531
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10.1186/gb-2001-2-1-research0003
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T Hastie, R Tibshirani, J Friedman The Elements of Statistical Learning; Data Mining, Inference and Prediction (Springer, New York, 2001). / The Elements of Statistical Learning; Data Mining, Inference and Prediction by Hastie T (2001)
10.1073/pnas.95.25.14863
10.1073/pnas.091062498
10.1093/biomet/81.3.425
R Tibshirani J R Stat Soc B 58, 267–288 (1996). (10.1111/j.2517-6161.1996.tb02080.x) / J R Stat Soc B by Tibshirani R (1996)
H Kovar, M Dworzak, S Strehl Oncogene 5, 1067–1070 (1990). / Oncogene by Kovar H (1990)
10.1097/00019606-199802000-00007
M Altmannsberger, K Weber, R Droste, M Osborn Am J Pathol 118, 85–95 (1985). / Am J Pathol by Altmannsberger M (1985)
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10.1054/bjoc.2001.2008
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L Breiman Mach Learn 26, 123–140 (1996). / Mach Learn by Breiman L (1996)

Dates

Type	When
Created	23 years ago (July 26, 2002, 10:46 a.m.)
Deposited	8 months, 2 weeks ago (Dec. 7, 2024, 5:38 p.m.)
Indexed	2 days, 3 hours ago (Aug. 22, 2025, 12:45 a.m.)
Issued	23 years, 3 months ago (May 14, 2002)
Published	23 years, 3 months ago (May 14, 2002)
Published Online	23 years, 3 months ago (May 14, 2002)
Published Print	23 years, 3 months ago (May 14, 2002)

Funders 0

None

BibTeX

@article{Tibshirani_2002, title={Diagnosis of multiple cancer types by shrunken centroids of gene expression}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.082099299}, DOI={10.1073/pnas.082099299}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Tibshirani, Robert and Hastie, Trevor and Narasimhan, Balasubramanian and Chu, Gilbert}, year={2002}, month=may, pages={6567–6572} }

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