DOI: 10.1073/pnas.081061898. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

10.1073/pnas.081061898

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In laboratory rodents, caloric restriction (CR) retards several age-dependent physiological and biochemical changes in skeletal muscle, including increased steady-state levels of oxidative damage to lipids, DNA, and proteins. We have previously used high-density oligonucleotide arrays to show that CR can prevent or delay most of the major age-related transcriptional alterations in the gastrocnemius muscle of C57BL/6 mice. Here we report the effects of aging and adult-onset CR on the gene expression profile of 7,070 genes in the vastus lateralis muscle from rhesus monkeys. Gene expression analysis of aged rhesus monkeys (mean age of 26 years) was compared with that of young animals (mean age of 8 years). Aging resulted in a selective up-regulation of transcripts involved in inflammation and oxidative stress, and a down-regulation of genes involved in mitochondrial electron transport and oxidative phosphorylation. Middle-aged monkeys (mean age of 20 years) subjected to CR since early adulthood (mean age of 11 years) were studied to determine the gene expression profile induced by CR. CR resulted in an up-regulation of cytoskeletal protein-encoding genes, and also a decrease in the expression of genes involved in mitochondrial bioenergetics. Surprisingly, we did not observe any evidence for an inhibitory effect of adult-onset CR on age-related changes in gene expression. These results indicate that the induction of an oxidative stress-induced transcriptional response may be a common feature of aging in skeletal muscle of rodents and primates, but the extent to which CR modifies these responses may be species-specific.

Bibliography

Kayo, T., Allison, D. B., Weindruch, R., & Prolla, T. A. (2001). Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proceedings of the National Academy of Sciences, 98(9), 5093â5098.

Authors 4

Tsuyoshi Kayo (first)
David B. Allison (additional)
Richard Weindruch (additional)
Tomas A. Prolla (additional)

References 26 Referenced 290

R Weindruch, R L Walford The Retardation of Aging and Disease by Dietary Restriction (Thomas, Springfield, IL, 1988). / The Retardation of Aging and Disease by Dietary Restriction by Weindruch R (1988)
10.1126/science.285.5432.1390
10.1038/77046
10.1093/geronj/48.1.B17
10.1093/geronj/45.5.B148
W M Kohrt, J O Holloszy J Gerontol A Biol Sci Med Sci 50, 68–72 (1995). / J Gerontol A Biol Sci Med Sci by Kohrt W M (1995)
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10.1016/S0891-5849(00)00303-8
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10.1111/j.1748-1716.1995.tb09941.x
10.1111/j.1432-1033.1992.tb17044.x
10.1111/j.1432-1033.1989.tb15015.x
10.1016/0378-1119(94)90158-9
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10.1096/fj.99-0881com
J W Kemnitz, E B Roecker, R Weindruch, D F Elson, S T Baum, R N Bergman Am J Physiol 266, E540–E547 (1994). / Am J Physiol by Kemnitz J W (1994)
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10.1093/jn/127.12.2293

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:44 a.m.)
Deposited	3 years, 4 months ago (April 25, 2022, 8:33 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 1:25 a.m.)
Issued	24 years, 4 months ago (April 17, 2001)
Published	24 years, 4 months ago (April 17, 2001)
Published Online	24 years, 4 months ago (April 17, 2001)
Published Print	24 years, 4 months ago (April 24, 2001)

Funders 0

None

BibTeX

@article{Kayo_2001, title={Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.081061898}, DOI={10.1073/pnas.081061898}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kayo, Tsuyoshi and Allison, David B. and Weindruch, Richard and Prolla, Tomas A.}, year={2001}, month=apr, pages={5093–5098} }

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