DOI: 10.1073/pnas.0809467105. A unique cell division machinery in the Archaea

A unique cell division machinery in the Archaea

10.1073/pnas.0809467105

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In contrast to the cell division machineries of bacteria, euryarchaea, and eukaryotes, no division components have been identified in the second main archaeal phylum, Crenarchaeota. Here, we demonstrate that a three-gene operon, cdv , in the crenarchaeon Sulfolobus acidocaldarius , forms part of a unique cell division machinery. The operon is induced at the onset of genome segregation and division, and the Cdv proteins then polymerize between segregating nucleoids and persist throughout cell division, forming a successively smaller structure during constriction. The cdv operon is dramatically down-regulated after UV irradiation, indicating division inhibition in response to DNA damage, reminiscent of eukaryotic checkpoint systems. The cdv genes exhibit a complementary phylogenetic range relative to FtsZ-based archaeal division systems such that, in most archaeal lineages, either one or the other system is present. Two of the Cdv proteins, CdvB and CdvC, display homology to components of the eukaryotic ESCRT-III sorting complex involved in budding of luminal vesicles and HIV-1 virion release, suggesting mechanistic similarities and a common evolutionary origin.

Bibliography

LindÃ¥s, A.-C., Karlsson, E. A., Lindgren, M. T., Ettema, T. J. G., & Bernander, R. (2008). A unique cell division machinery in the Archaea. Proceedings of the National Academy of Sciences, 105(48), 18942â18946.

Authors 5

Ann-Christin Lindås (first)
Erik A. Karlsson (additional)
Maria T. Lindgren (additional)
Thijs J. G. Ettema (additional)
Rolf Bernander (additional)

References 31 Referenced 277

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Dates

Type	When
Created	16 years, 9 months ago (Nov. 5, 2008, 9:25 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 5:38 p.m.)
Indexed	1 month, 1 week ago (July 23, 2025, 8:52 a.m.)
Issued	16 years, 8 months ago (Dec. 2, 2008)
Published	16 years, 8 months ago (Dec. 2, 2008)
Published Online	16 years, 8 months ago (Dec. 2, 2008)
Published Print	16 years, 8 months ago (Dec. 2, 2008)

Funders 0

None

BibTeX

@article{Lind_s_2008, title={A unique cell division machinery in the Archaea}, volume={105}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0809467105}, DOI={10.1073/pnas.0809467105}, number={48}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Lindås, Ann-Christin and Karlsson, Erik A. and Lindgren, Maria T. and Ettema, Thijs J. G. and Bernander, Rolf}, year={2008}, month=dec, pages={18942–18946} }

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