DOI: 10.1073/pnas.0804717105. MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus

MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus

10.1073/pnas.0804717105

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Infection by RNA viruses is detected by the host through Toll-like receptors or RIG-I-like receptors. Toll-like receptors and RIG-I-like receptors signal through the adaptors MyD88 and MAVS, respectively, to induce type I IFNs (IFN-I) and other antiviral molecules, which are thought to be essential for activating the adaptive immune system. We investigated the role of these adaptors in innate and adaptive immune responses against respiratory syncytial virus (RSV), a common human pathogen. Deletion ofMavsabolished the induction of IFN-I and other proinflammatory cytokines by RSV. Genome-wide expression profiling in the lung showed that the vast majority of RSV-induced genes depended on MAVS. AlthoughMyd88deficiency did not affect most RSV-induced genes, mice lacking both adaptors harbored a higher and more prolonged viral load and exhibited more severe pulmonary disease than those lacking either adaptor alone. Surprisingly,Myd88−/−Mavs−/−mice were able to activate a subset of pulmonary dendritic cells that traffic to the draining lymph node in response to RSV. These mice subsequently mounted a normal cytotoxic T-lymphocyte response and demonstrated delayed but effective viral clearance. These results provide an example of a normal and effective adaptive immune response in the absence of innate immunity mediated by MAVS and MyD88.

Bibliography

Bhoj, V. G., Sun, Q., Bhoj, E. J., Somers, C., Chen, X., Torres, J.-P., Mejias, A., Gomez, A. M., Jafri, H., Ramilo, O., & Chen, Z. J. (2008). MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proceedings of the National Academy of Sciences, 105(37), 14046â14051.

Authors 11

Vijay G. Bhoj (first)
Qinmiao Sun (additional)
Elizabeth J. Bhoj (additional)
Cynthia Somers (additional)
Xiang Chen (additional)
Juan-Pablo Torres (additional)
Asuncion Mejias (additional)
Ana M. Gomez (additional)
Hasan Jafri (additional)
Octavio Ramilo (additional)
Zhijian J. Chen (additional)

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Dates

Type	When
Created	16 years, 11 months ago (Sept. 9, 2008, 9:06 p.m.)
Deposited	2 years, 3 months ago (May 19, 2023, 6:13 p.m.)
Indexed	3 months ago (May 20, 2025, 5:22 p.m.)
Issued	16 years, 11 months ago (Sept. 16, 2008)
Published	16 years, 11 months ago (Sept. 16, 2008)
Published Online	16 years, 11 months ago (Sept. 16, 2008)
Published Print	16 years, 11 months ago (Sept. 16, 2008)

Funders 0

None

BibTeX

@article{Bhoj_2008, title={MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus}, volume={105}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0804717105}, DOI={10.1073/pnas.0804717105}, number={37}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Bhoj, Vijay G. and Sun, Qinmiao and Bhoj, Elizabeth J. and Somers, Cynthia and Chen, Xiang and Torres, Juan-Pablo and Mejias, Asuncion and Gomez, Ana M. and Jafri, Hasan and Ramilo, Octavio and Chen, Zhijian J.}, year={2008}, month=sep, pages={14046–14051} }

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