DOI: 10.1073/pnas.071034098. Free energy reconstruction from nonequilibrium single-molecule pulling experiments

Free energy reconstruction from nonequilibrium single-molecule pulling experiments

10.1073/pnas.071034098

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Laser tweezers and atomic force microscopes are increasingly used to probe the interactions and mechanical properties of individual molecules. Unfortunately, using such time-dependent perturbations to force rare molecular events also drives the system away from equilibrium. Nevertheless, we show how equilibrium free energy profiles can be extracted rigorously from repeated nonequilibrium force measurements on the basis of an extension of Jarzynski's remarkable identity between free energies and the irreversible work.

Bibliography

Hummer, G., & Szabo, A. (2001). Free energy reconstruction from nonequilibrium single-molecule pulling experiments. Proceedings of the National Academy of Sciences, 98(7), 3658â3661.

Authors 2

Gerhard Hummer (first)
Attila Szabo (additional)

References 22 Referenced 786

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:44 a.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 4:06 p.m.)
Indexed	2 days, 12 hours ago (Sept. 3, 2025, 6:51 a.m.)
Issued	24 years, 5 months ago (March 27, 2001)
Published	24 years, 5 months ago (March 27, 2001)
Published Online	24 years, 5 months ago (March 27, 2001)
Published Print	24 years, 5 months ago (March 27, 2001)

Funders 0

None

BibTeX

@article{Hummer_2001, title={Free energy reconstruction from nonequilibrium single-molecule pulling experiments}, volume={98}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.071034098}, DOI={10.1073/pnas.071034098}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hummer, Gerhard and Szabo, Attila}, year={2001}, month=mar, pages={3658–3661} }

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