DOI: 10.1073/pnas.0709144105. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

10.1073/pnas.0709144105

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Increasing the size and strength of muscles represents a promising therapeutic strategy for musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of muscle growth. Various myostatin inhibitor approaches have been identified and tested in models of muscle disease with varying efficacies, depending on the age at which myostatin inhibition occurs. Here, we describe a one-time gene administration of myostatin-inhibitor-proteins to enhance muscle mass and strength in normal and dystrophic mouse models for >2 years, even when delivered in aged animals. These results demonstrate a promising therapeutic strategy that warrants consideration for clinical trials in human muscle diseases.

Bibliography

Haidet, A. M., Rizo, L., Handy, C., Umapathi, P., Eagle, A., Shilling, C., Boue, D., Martin, P. T., Sahenk, Z., Mendell, J. R., & Kaspar, B. K. (2008). Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proceedings of the National Academy of Sciences, 105(11), 4318â4322.

Authors 11

Amanda M. Haidet (first)
Liza Rizo (additional)
Chalonda Handy (additional)
Priya Umapathi (additional)
Amy Eagle (additional)
Chris Shilling (additional)
Daniel Boue (additional)
Paul T. Martin (additional)
Zarife Sahenk (additional)
Jerry R. Mendell (additional)
Brian K. Kaspar (additional)

References 27 Referenced 217

Dates

Type	When
Created	17 years, 5 months ago (March 11, 2008, 11:45 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 4:13 p.m.)
Indexed	4 weeks, 1 day ago (July 30, 2025, 11:02 a.m.)
Issued	17 years, 5 months ago (March 18, 2008)
Published	17 years, 5 months ago (March 18, 2008)
Published Online	17 years, 5 months ago (March 18, 2008)
Published Print	17 years, 5 months ago (March 18, 2008)

Funders 0

None

BibTeX

@article{Haidet_2008, title={Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors}, volume={105}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0709144105}, DOI={10.1073/pnas.0709144105}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Haidet, Amanda M. and Rizo, Liza and Handy, Chalonda and Umapathi, Priya and Eagle, Amy and Shilling, Chris and Boue, Daniel and Martin, Paul T. and Sahenk, Zarife and Mendell, Jerry R. and Kaspar, Brian K.}, year={2008}, month=mar, pages={4318–4322} }

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