DOI: 10.1073/pnas.0703285104. Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells

Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells

10.1073/pnas.0703285104

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Virus infection triggers IFN immune defenses in infected cells in part through viral nucleic acid interactions, but the pathways by which dsDNA and DNA viruses trigger innate defenses are only partially understood. Here we present evidence that both retinoic acid-induced gene I (RIG-I) and mitochondrial antiviral signaling protein (MAVS) are required for dsDNA-induced IFN-β promoter activation in a human hepatoma cell line (Huh-7), and that activation is efficiently blocked by the hepatitis C virus NS3/4A protease, which is known to block dsRNA signaling by cleaving MAVS. These findings suggest that dsDNA and dsRNA share a common pathway to trigger the innate antiviral defense response in human cells, although dsDNA appears to trigger that pathway upstream of the dsRNA-interacting protein RIG-I.

Authors 4

Guofeng Cheng (first)
Jin Zhong (additional)
Josan Chung (additional)
Francis V. Chisari (additional)

References 33 Referenced 130

Dates

Type	When
Created	18 years, 3 months ago (May 15, 2007, 9:41 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 4:38 p.m.)
Indexed	4 months, 2 weeks ago (April 11, 2025, 8:27 a.m.)
Issued	18 years, 3 months ago (May 22, 2007)
Published	18 years, 3 months ago (May 22, 2007)
Published Online	18 years, 3 months ago (May 22, 2007)
Published Print	18 years, 3 months ago (May 22, 2007)

Funders 0

None

BibTeX

@article{Cheng_2007, title={Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells}, volume={104}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0703285104}, DOI={10.1073/pnas.0703285104}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Cheng, Guofeng and Zhong, Jin and Chung, Josan and Chisari, Francis V.}, year={2007}, month=may, pages={9035–9040} }

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