DOI: 10.1073/pnas.070022697. Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus

Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus

10.1073/pnas.070022697

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The neural cell adhesion molecule (NCAM) and its polysialylated form (PSA-NCAM) contribute to long-term potentiation (LTP) in the CA1 hippocampus. Here we report that the deficient LTP found in slices prepared from NCAM knockout mice and in organotypic slice cultures treated with Endo-N, an enzyme that cleaves the PSA moiety of NCAM, can be rescued by brain-derived neurotrophic factor (BDNF). This effect is not reproduced by nerve growth factor, but can be obtained with high concentrations of NT4/5. The effect of BDNF cannot be accounted for by modifications of N -methyl- d -aspartate receptor-dependent responses or of high-frequency bursts. PSA-NCAM, however, could directly interact with BDNF. Exogenous application of PSA residues or recombinant PSA-NCAM also prevents LTP. Furthermore trkB phosphorylation, and thus BDNF signaling, is reduced in both NCAM knockout mice and Endo-N-treated slice cultures. These results suggest that one action of PSA-NCAM could be to sensitize pyramidal neurons to BDNF, thereby modulating activity-dependent synaptic plasticity.

Bibliography

Muller, D., Djebbara-Hannas, Z., Jourdain, P., Vutskits, L., Durbec, P., Rougon, G., & Kiss, J. Z. (2000). Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus. Proceedings of the National Academy of Sciences, 97(8), 4315â4320.

Authors 7

D. Muller (first)
Z. Djebbara-Hannas (additional)
P. Jourdain (additional)
L. Vutskits (additional)
P. Durbec (additional)
G. Rougon (additional)
J. Z. Kiss (additional)

References 39 Referenced 173

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 10:41 a.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 2:51 p.m.)
Indexed	16 minutes ago (Sept. 4, 2025, 9:40 a.m.)
Issued	25 years, 5 months ago (March 21, 2000)
Published	25 years, 5 months ago (March 21, 2000)
Published Online	25 years, 5 months ago (March 21, 2000)
Published Print	25 years, 4 months ago (April 11, 2000)

Funders 0

None

BibTeX

@article{Muller_2000, title={Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus}, volume={97}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.070022697}, DOI={10.1073/pnas.070022697}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Muller, D. and Djebbara-Hannas, Z. and Jourdain, P. and Vutskits, L. and Durbec, P. and Rougon, G. and Kiss, J. Z.}, year={2000}, month=mar, pages={4315–4320} }

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