DOI: 10.1073/pnas.0636761100. A conserved function of YidC in the biogenesis of respiratory chain complexes

A conserved function of YidC in the biogenesis of respiratory chain complexes

10.1073/pnas.0636761100

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The Escherichia coli inner membrane protein (IMP) YidC is involved in the membrane integration of IMPs both in concert with and independently from the Sec translocase. YidC seems to be dispensable for the assembly of Sec-dependent IMPs, and so far it has been shown to be essential only for the proper Sec-independent integration of some phage coat proteins. Here, we studied the physiological consequences of YidC depletion in an effort to understand the essential function of YidC. The loss of YidC rapidly and specifically induced the Psp stress response, which is accompanied by a reduction of the proton-motive force. This reduction is due to defects in the functional assembly of cytochrome o oxidase and the F 1 F o ATPase complex, which is reminiscent of the effects of mutations in the yidC homologue OXA1 in the yeast mitochondrial inner membrane. The integration of CyoA (subunit II of the cytochrome o oxidase) and F o c (membrane subunit of the F 1 F o ATPase) appeared exceptionally sensitive to depletion of YidC, suggesting that these IMPs are natural substrates of a membrane integration and assembly pathway in which YidC plays an exclusive or at least a pivotal role.

Bibliography

van der Laan, M., Urbanus, M. L., ten Hagen-Jongman, C. M., Nouwen, N., Oudega, B., Harms, N., Driessen, A. J. M., & Luirink, J. (2003). A conserved function of YidC in the biogenesis of respiratory chain complexes. Proceedings of the National Academy of Sciences, 100(10), 5801â5806.

Authors 8

M. van der Laan (first)
M. L. Urbanus (additional)
C. M. ten Hagen-Jongman (additional)
N. Nouwen (additional)
B. Oudega (additional)
N. Harms (additional)
A. J. M. Driessen (additional)
J. Luirink (additional)

References 40 Referenced 129

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Dates

Type	When
Created	22 years, 3 months ago (May 13, 2003, 2:28 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 2:46 p.m.)
Indexed	3 months, 4 weeks ago (April 30, 2025, 12:26 a.m.)
Issued	22 years, 3 months ago (April 30, 2003)
Published	22 years, 3 months ago (April 30, 2003)
Published Online	22 years, 3 months ago (April 30, 2003)
Published Print	22 years, 3 months ago (May 13, 2003)

Funders 0

None

BibTeX

@article{van_der_Laan_2003, title={A conserved function of YidC in the biogenesis of respiratory chain complexes}, volume={100}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0636761100}, DOI={10.1073/pnas.0636761100}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={van der Laan, M. and Urbanus, M. L. and ten Hagen-Jongman, C. M. and Nouwen, N. and Oudega, B. and Harms, N. and Driessen, A. J. M. and Luirink, J.}, year={2003}, month=apr, pages={5801–5806} }

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