DOI: 10.1073/pnas.062065699. Genes directly controlled by CtrA, a master regulator of the <i>Caulobacter</i> cell cycle

Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle

10.1073/pnas.062065699

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Studies of the genetic network that controls the Caulobacter cell cycle have identified a response regulator, CtrA, that controls, directly or indirectly, one-quarter of the 553 cell cycle-regulated genes. We have performed in vivo genomic binding site analysis of the CtrA protein to identify which of these genes have regulatory regions bound directly by CtrA. By combining these data with previous global analysis of cell cycle transcription patterns and gene expression profiles of mutant ctrA strains, we have determined that CtrA directly regulates at least 95 genes. The total group of CtrA-regulated genes includes those involved in polar morphogenesis, DNA replication initiation, DNA methylation, cell division, and cell wall metabolism. Also among the genes in this notably large regulon are 14 that encode regulatory proteins, including 10 two-component signal transduction regulatory proteins. Identification of additional regulatory genes activated by CtrA will serve to directly connect new regulatory modules to the network controlling cell cycle progression.

Bibliography

Laub, M. T., Chen, S. L., Shapiro, L., & McAdams, H. H. (2002). Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle. Proceedings of the National Academy of Sciences, 99(7), 4632â4637.

Authors 4

Michael T. Laub (first)
Swaine L. Chen (additional)
Lucy Shapiro (additional)
Harley H. McAdams (additional)

References 26 Referenced 340

10.1038/83751
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Dates

Type	When
Created	23 years ago (July 26, 2002, 10:37 a.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 3:39 p.m.)
Indexed	5 days, 15 hours ago (Aug. 19, 2025, 6:37 a.m.)
Issued	23 years, 4 months ago (April 2, 2002)
Published	23 years, 4 months ago (April 2, 2002)
Published Online	23 years, 4 months ago (April 2, 2002)
Published Print	23 years, 4 months ago (April 2, 2002)

Funders 0

None

BibTeX

@article{Laub_2002, title={Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle}, volume={99}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.062065699}, DOI={10.1073/pnas.062065699}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Laub, Michael T. and Chen, Swaine L. and Shapiro, Lucy and McAdams, Harley H.}, year={2002}, month=apr, pages={4632–4637} }

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