DOI: 10.1073/pnas.0610660104. Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis

Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis

10.1073/pnas.0610660104

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Spinal muscular atrophy (SMA) is an autosomal recessive disease of childhood due to loss of the telomeric survival motor neuron gene, SMN1 . The general functions of the main SMN1 protein product, full-length SMN (FL-SMN), do not explain the selective motoneuronal loss of SMA. We identified axonal-SMN (a-SMN), an alternatively spliced SMN form, preferentially encoded by the SMN1 gene in humans. The a-SMN transcript and protein are down-regulated during early development in different tissues. In the spinal cord, the a-SMN protein is selectively expressed in motor neurons and mainly localized in axons. Forced expression of a-SMN stimulates motor neuron axonogenesis in a time-dependent fashion and induces axonal-like growth in non-neuronal cells. Exons 2b and 3 are essential for the axonogenic effects. This discovery indicates an unexpected complexity of the SMN gene system and may help in understanding the pathogenesis of SMA.

Bibliography

Setola, V., Terao, M., Locatelli, D., Bassanini, S., Garattini, E., & Battaglia, G. (2007). Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis. Proceedings of the National Academy of Sciences, 104(6), 1959â1964.

Authors 6

Veronica Setola (first)
Mineko Terao (additional)
Denise Locatelli (additional)
Stefania Bassanini (additional)
Enrico Garattini (additional)
Giorgio Battaglia (additional)

References 46 Referenced 63

Dates

Type	When
Created	18 years, 6 months ago (Feb. 2, 2007, 1:37 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 2:50 p.m.)
Indexed	1 year ago (Aug. 10, 2024, 12:33 p.m.)
Issued	18 years, 6 months ago (Feb. 6, 2007)
Published	18 years, 6 months ago (Feb. 6, 2007)
Published Online	18 years, 6 months ago (Feb. 6, 2007)
Published Print	18 years, 6 months ago (Feb. 6, 2007)

Funders 0

None

BibTeX

@article{Setola_2007, title={Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis}, volume={104}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0610660104}, DOI={10.1073/pnas.0610660104}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Setola, Veronica and Terao, Mineko and Locatelli, Denise and Bassanini, Stefania and Garattini, Enrico and Battaglia, Giorgio}, year={2007}, month=feb, pages={1959–1964} }

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