DOI: 10.1073/pnas.0610542104. Core-controlled polymorphism in virus-like particles

Core-controlled polymorphism in virus-like particles

10.1073/pnas.0610542104

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

This study concerns the self-assembly of virus-like particles (VLPs) composed of an icosahedral virus protein coat encapsulating a functionalized spherical nanoparticle core. The recent development of efficient methods for VLP self-assembly has opened the way to structural studies. Using electron microscopy with image reconstruction, the structures of several VLPs obtained from brome mosaic virus capsid proteins and gold nanoparticles were elucidated. Varying the gold core diameter provides control over the capsid structure. The number of subunits required for a complete capsid increases with the core diameter. The packaging efficiency is a function of the number of capsid protein subunits per gold nanoparticle. VLPs of varying diameters were found to resemble to three classes of viral particles found in cells ( T = 1, 2, and 3). As a consequence of their regularity, VLPs form three-dimensional crystals under the same conditions as the wild-type virus. The crystals represent a form of metallodielectric material that exhibits optical properties influenced by multipolar plasmonic coupling.

Bibliography

Sun, J., DuFort, C., Daniel, M.-C., Murali, A., Chen, C., Gopinath, K., Stein, B., De, M., Rotello, V. M., Holzenburg, A., Kao, C. C., & Dragnea, B. (2007). Core-controlled polymorphism in virus-like particles. Proceedings of the National Academy of Sciences, 104(4), 1354â1359.

Authors 12

Jingchuan Sun (first)
Chris DuFort (additional)
Marie-Christine Daniel (additional)
Ayaluru Murali (additional)
Chao Chen (additional)
Kodetham Gopinath (additional)
Barry Stein (additional)
Mrinmoy De (additional)
Vincent M. Rotello (additional)
Andreas Holzenburg (additional)
C. Cheng Kao (additional)
Bogdan Dragnea (additional)

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Dates

Type	When
Created	18 years, 7 months ago (Jan. 16, 2007, 10:18 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 2:44 p.m.)
Indexed	3 weeks, 5 days ago (Aug. 2, 2025, 12:33 a.m.)
Issued	18 years, 7 months ago (Jan. 23, 2007)
Published	18 years, 7 months ago (Jan. 23, 2007)
Published Online	18 years, 7 months ago (Jan. 23, 2007)
Published Print	18 years, 7 months ago (Jan. 23, 2007)

Funders 0

None

BibTeX

@article{Sun_2007, title={Core-controlled polymorphism in virus-like particles}, volume={104}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0610542104}, DOI={10.1073/pnas.0610542104}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Sun, Jingchuan and DuFort, Chris and Daniel, Marie-Christine and Murali, Ayaluru and Chen, Chao and Gopinath, Kodetham and Stein, Barry and De, Mrinmoy and Rotello, Vincent M. and Holzenburg, Andreas and Kao, C. Cheng and Dragnea, Bogdan}, year={2007}, month=jan, pages={1354–1359} }

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