DOI: 10.1073/pnas.0605838103. Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5α

Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5α

10.1073/pnas.0605838103

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Retroviral restriction factor TRIM5α exhibits a high degree of sequence variation among primate species. It has been proposed that this diversity is the cumulative result of ancient, lineage-specific episodes of positive selection. Here, we describe the contribution of within-species variation to the evolution of TRIM5α. Sampling within two geographically distinct Old World monkey species revealed extensive polymorphism, including individual polymorphisms that predate speciation (shared polymorphism). In some instances, alleles were more closely related to orthologues of other species than to one another. Both silent and nonsynonymous changes clustered in two domains. Functional assays revealed consequences of polymorphism, including differential restriction of a small panel of retroviruses by very similar alleles. Together, these features indicate that the primate TRIM5α locus has evolved under balancing selection. Except for the MHC there are few, if any, examples of long-term balancing selection in primates. Our results suggest a complex evolutionary scenario, in which fixation of lineage-specific adaptations is superimposed on a subset of critical polymorphisms that predate speciation events and have been maintained by balancing selection for millions of years.

Bibliography

Newman, R. M., Hall, L., Connole, M., Chen, G.-L., Sato, S., Yuste, E., Diehl, W., Hunter, E., Kaur, A., Miller, G. M., & Johnson, W. E. (2006). Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5Î±. Proceedings of the National Academy of Sciences, 103(50), 19134â19139.

Authors 11

Ruchi M. Newman (first)
Laura Hall (additional)
Michelle Connole (additional)
Guo-Lin Chen (additional)
Shuji Sato (additional)
Eloisa Yuste (additional)
William Diehl (additional)
Eric Hunter (additional)
Amitinder Kaur (additional)
Gregory M. Miller (additional)
Welkin E. Johnson (additional)

References 67 Referenced 138

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Dates

Type	When
Created	18 years, 9 months ago (Dec. 1, 2006, 8:34 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 3:05 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 6, 2025, 9:24 a.m.)
Issued	18 years, 8 months ago (Dec. 12, 2006)
Published	18 years, 8 months ago (Dec. 12, 2006)
Published Online	18 years, 8 months ago (Dec. 12, 2006)
Published Print	18 years, 8 months ago (Dec. 12, 2006)

Funders 0

None

BibTeX

@article{Newman_2006, title={Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5α}, volume={103}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0605838103}, DOI={10.1073/pnas.0605838103}, number={50}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Newman, Ruchi M. and Hall, Laura and Connole, Michelle and Chen, Guo-Lin and Sato, Shuji and Yuste, Eloisa and Diehl, William and Hunter, Eric and Kaur, Amitinder and Miller, Gregory M. and Johnson, Welkin E.}, year={2006}, month=dec, pages={19134–19139} }

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