DOI: 10.1073/pnas.0605832103. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

10.1073/pnas.0605832103

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age ( P < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association ( P < 4.2 × 10 −9 ) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.

Bibliography

Freedman, M. L., Haiman, C. A., Patterson, N., McDonald, G. J., Tandon, A., Waliszewska, A., Penney, K., Steen, R. G., Ardlie, K., John, E. M., Oakley-Girvan, I., Whittemore, A. S., Cooney, K. A., Ingles, S. A., Altshuler, D., Henderson, B. E., & Reich, D. (2006). Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proceedings of the National Academy of Sciences, 103(38), 14068â14073.

Authors 17

Matthew L. Freedman (first)
Christopher A. Haiman (additional)
Nick Patterson (additional)
Gavin J. McDonald (additional)
Arti Tandon (additional)
Alicja Waliszewska (additional)
Kathryn Penney (additional)
Robert G. Steen (additional)
Kristin Ardlie (additional)
Esther M. John (additional)
Ingrid Oakley-Girvan (additional)
Alice S. Whittemore (additional)
Kathleen A. Cooney (additional)
Sue A. Ingles (additional)
David Altshuler (additional)
Brian E. Henderson (additional)
David Reich (additional)

References 26 Referenced 518

10.3322/canjclin.56.2.106
CH Bunker, AL Patrick, BR Konety, R Dhir, AM Brufsky, CA Vivas, MJ Becich, DL Trump, LH Kuller Cancer Epidemiol Biomarkers Prev 11, 726–729 (2002). / Cancer Epidemiol Biomarkers Prev by Bunker CH (2002)
10.1002/pros.20052
10.1677/erc.0.0100225
10.1086/420856
PM McKeigue Am J Hum Genet 60, 188–196 (1997). / Am J Hum Genet by McKeigue PM (1997)
DC Rife Am J Hum Genet 6, 26–33 (1954). / Am J Hum Genet by Rife DC (1954)
10.1086/420871
10.1086/420855
10.1086/425281
10.1038/ng1510
10.1038/ng1646
10.1038/ng1808
10.1093/oxfordjournals.aje.a010213
10.1158/0008-5472.CAN-04-3134
10.1016/S0090-4295(00)00873-6
10.1093/jnci/89.13.955
10.1007/s00439-002-0731-5
10.1093/jnci/83.17.1231
10.1002/gcc.20259
T Visakorpi, AH Kallioniemi, AC Syvanen, ER Hyytinen, R Karhu, T Tammela, JJ Isola, OP Kallioniemi Cancer Res 55, 342–347 (1995). / Cancer Res by Visakorpi T (1995)
10.1016/S1535-6108(03)00197-1
10.1002/pros.20200
10.1101/sqb.2003.68.69
10.1073/pnas.96.18.10016
10.1038/nature04226

Dates

Type	When
Created	18 years, 11 months ago (Aug. 31, 2006, 8:38 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 2:39 p.m.)
Indexed	1 week, 2 days ago (Aug. 20, 2025, 8:34 a.m.)
Issued	18 years, 11 months ago (Sept. 19, 2006)
Published	18 years, 11 months ago (Sept. 19, 2006)
Published Online	18 years, 11 months ago (Sept. 19, 2006)
Published Print	18 years, 11 months ago (Sept. 19, 2006)

Funders 0

None

BibTeX

@article{Freedman_2006, title={Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men}, volume={103}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0605832103}, DOI={10.1073/pnas.0605832103}, number={38}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Freedman, Matthew L. and Haiman, Christopher A. and Patterson, Nick and McDonald, Gavin J. and Tandon, Arti and Waliszewska, Alicja and Penney, Kathryn and Steen, Robert G. and Ardlie, Kristin and John, Esther M. and Oakley-Girvan, Ingrid and Whittemore, Alice S. and Cooney, Kathleen A. and Ingles, Sue A. and Altshuler, David and Henderson, Brian E. and Reich, David}, year={2006}, month=sep, pages={14068–14073} }

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  "abstract": "<jats:p>\n            A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age (\n            <jats:italic>P</jats:italic>\n            &lt; 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association (\n            <jats:italic>P</jats:italic>\n            &lt; 4.2 \u00d7 10\n            <jats:sup>\u22129</jats:sup>\n            ) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it.\n          </jats:p>",
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