DOI: 10.1073/pnas.0603101103. Precise adaptation in bacterial chemotaxis through “assistance neighborhoods”

Precise adaptation in bacterial chemotaxis through “assistance neighborhoods”

10.1073/pnas.0603101103

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The chemotaxis network in Escherichia coli is remarkable for its sensitivity to small relative changes in the concentrations of multiple chemical signals over a broad range of ambient concentrations. Key to this sensitivity is an adaptation system that relies on methylation and demethylation (or deamidation) of specific modification sites of the chemoreceptors by the enzymes CheR and CheB, respectively. It was recently discovered that these enzymes can access five to seven receptors when tethered to a particular receptor. We show that these “assistance neighborhoods” are necessary for precise adaptation in a model for signaling by clusters of chemoreceptors. In agreement with experiment, model clusters composed of receptors of different types exhibit high sensitivity and precise adaptation over a wide range of chemical concentrations and the response of adapted clusters to addition/removal of attractant scales with free-energy change. We predict two limits of precise adaptation at large attractant concentrations: Either receptors reach full methylation and turn off, or receptors become saturated and cease to respond to attractant but retain their adapted activity.

Bibliography

Endres, R. G., & Wingreen, N. S. (2006). Precise adaptation in bacterial chemotaxis through âassistance neighborhoods.â Proceedings of the National Academy of Sciences, 103(35), 13040â13044.

Authors 2

Robert G. Endres (first)
Ned S. Wingreen (additional)

References 31 Referenced 135

Dates

Type	When
Created	19 years ago (Aug. 21, 2006, 8:39 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 2:59 p.m.)
Indexed	2 weeks, 2 days ago (Aug. 6, 2025, 9:11 a.m.)
Issued	18 years, 11 months ago (Aug. 29, 2006)
Published	18 years, 11 months ago (Aug. 29, 2006)
Published Online	18 years, 11 months ago (Aug. 29, 2006)
Published Print	18 years, 11 months ago (Aug. 29, 2006)

Funders 0

None

BibTeX

@article{Endres_2006, title={Precise adaptation in bacterial chemotaxis through “assistance neighborhoods”}, volume={103}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0603101103}, DOI={10.1073/pnas.0603101103}, number={35}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Endres, Robert G. and Wingreen, Ned S.}, year={2006}, month=aug, pages={13040–13044} }

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