DOI: 10.1073/pnas.0602142103. Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1β

Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1β

10.1073/pnas.0602142103

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high affinity, acting as a potent inhibitor of chemokine action. We have used heteronuclear multidimensional NMR to determine the structure of an orthopoxvirus vCCI in complex with a human CC chemokine, MIP-1β (macrophage inflammatory protein 1β). vCCI binds to the chemokine with 1:1 stoichiometry, forming a complex of 311 aa. vCCI uses residues from its β-sheet II to interact with a surface of MIP-1β that includes residues adjacent to its N terminus, as well as residues in the 20′s region and the 40′s loop. This structure reveals the strategy used by vCCI to tightly bind numerous chemokines while retaining selectivity for the CC chemokine subfamily.

Bibliography

Zhang, L., DeRider, M., McCornack, M. A., Jao, S., Isern, N., Ness, T., Moyer, R., & LiWang, P. J. (2006). Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1Î². Proceedings of the National Academy of Sciences, 103(38), 13985â13990.

Authors 8

Li Zhang (first)
Michele DeRider (additional)
Melissa A. McCornack (additional)
Shu-chuan Jao (additional)
Nancy Isern (additional)
Traci Ness (additional)
Richard Moyer (additional)
Patricia J. LiWang (additional)

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Dates

Type	When
Created	18 years, 11 months ago (Sept. 8, 2006, 9 p.m.)
Deposited	2 years, 3 months ago (May 8, 2023, 4:10 p.m.)
Indexed	11 months, 4 weeks ago (Aug. 28, 2024, 9:08 a.m.)
Issued	18 years, 11 months ago (Sept. 19, 2006)
Published	18 years, 11 months ago (Sept. 19, 2006)
Published Online	18 years, 11 months ago (Sept. 19, 2006)
Published Print	18 years, 11 months ago (Sept. 19, 2006)

Funders 0

None

BibTeX

@article{Zhang_2006, title={Solution structure of the complex between poxvirus-encoded CC chemokine inhibitor vCCI and human MIP-1β}, volume={103}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0602142103}, DOI={10.1073/pnas.0602142103}, number={38}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Zhang, Li and DeRider, Michele and McCornack, Melissa A. and Jao, Shu-chuan and Isern, Nancy and Ness, Traci and Moyer, Richard and LiWang, Patricia J.}, year={2006}, month=sep, pages={13985–13990} }

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