DOI: 10.1073/pnas.0501646102. Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites

Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites

10.1073/pnas.0501646102

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

To investigate retroviral integration targeting on a nucleotide scale, we examined the base frequencies directly surrounding cloned in vivo HIV-1, murine leukemia virus, and avian sarcoma/leukosis virus integrations. Base preferences of up to 2-fold the expected frequencies were found for three viruses, representing P values down to <10 -100 and defining what appear to be preferred integration sequences. Offset symmetry reflecting the topology of the integration reaction was found for HIV-1 and avian sarcoma/leukosis virus but not murine leukemia virus, suggesting fundamental differences in the way different retroviral integration complexes interact with host-cell DNA.

Bibliography

Holman, A. G., & Coffin, J. M. (2005). Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites. Proceedings of the National Academy of Sciences, 102(17), 6103â6107.

Authors 2

Alexander G. Holman (first)
John M. Coffin (additional)

References 12 Referenced 136

Dates

Type	When
Created	20 years, 4 months ago (March 31, 2005, 8:25 p.m.)
Deposited	3 years, 4 months ago (April 25, 2022, 10:39 p.m.)
Indexed	1 month, 1 week ago (July 22, 2025, 6:59 a.m.)
Issued	20 years, 4 months ago (March 31, 2005)
Published	20 years, 4 months ago (March 31, 2005)
Published Online	20 years, 4 months ago (March 31, 2005)
Published Print	20 years, 4 months ago (April 26, 2005)

Funders 0

None

BibTeX

@article{Holman_2005, title={Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites}, volume={102}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0501646102}, DOI={10.1073/pnas.0501646102}, number={17}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Holman, Alexander G. and Coffin, John M.}, year={2005}, month=mar, pages={6103–6107} }

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