DOI: 10.1073/pnas.0437746100. Regulatory gene networks and the properties of the developmental process

Regulatory gene networks and the properties of the developmental process

10.1073/pnas.0437746100

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.

Authors 3

Eric H. Davidson (first)
David R. McClay (additional)
Leroy Hood (additional)

References 38 Referenced 184

E H Davidson Genomic Regulatory Systems: Development and Evolution (Academic, San Diego, 2001). / Genomic Regulatory Systems: Development and Evolution by Davidson E H (2001)
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Dates

Type	When
Created	22 years, 6 months ago (Feb. 18, 2003, 3:04 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 2:18 p.m.)
Indexed	1 month, 1 week ago (July 25, 2025, 6:49 a.m.)
Issued	22 years, 6 months ago (Feb. 10, 2003)
Published	22 years, 6 months ago (Feb. 10, 2003)
Published Online	22 years, 6 months ago (Feb. 10, 2003)
Published Print	22 years, 6 months ago (Feb. 18, 2003)

Funders 0

None

BibTeX

@article{Davidson_2003, title={Regulatory gene networks and the properties of the developmental process}, volume={100}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0437746100}, DOI={10.1073/pnas.0437746100}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Davidson, Eric H. and McClay, David R. and Hood, Leroy}, year={2003}, month=feb, pages={1475–1480} }

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