DOI: 10.1073/pnas.0409918102. Genomic characterization of non-O1, non-O139 <i>Vibrio cholerae</i> reveals genes for a type III secretion system

Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system

10.1073/pnas.0409918102

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Non-O1, non-O139 Vibrio cholerae can cause gastroenteritis and extraintestinal infections, but, unlike O1 and O139 strains of V. cholerae , little is known about the virulence gene content of non-O1, non-O139 strains and their phylogenetic relationship to other pathogenic V. cholerae . Comparative genomic microarray analysis of four pathogenic non-O1, non-O139 strains indicates that these strains are quite divergent from O1 and O139 strains. Genomic sequence analysis of a non-O1, non-O139 strain (AM-19226) that appeared particularly pathogenic in experimental animals suggests that this strain carries a type III secretion system (TTSS) that is related to the TTSS2 gene cluster found in a pandemic clone of Vibrio parahaemolyticus . The genes for this V. cholerae TTSS system appear to be present in many clinical and environmental non-O1, non-O139 strains, including at least one clone that is globally distributed. We hypothesize that the TTSS present in some pathogenic strains of non-O1, non-O139 V. cholerae may be involved in the virulence and environmental fitness of these strains.

Bibliography

Dziejman, M., Serruto, D., Tam, V. C., Sturtevant, D., Diraphat, P., Faruque, S. M., Rahman, M. H., Heidelberg, J. F., Decker, J., Li, L., Montgomery, K. T., Grills, G., Kucherlapati, R., & Mekalanos, J. J. (2005). Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. Proceedings of the National Academy of Sciences, 102(9), 3465â3470.

Authors 14

Michelle Dziejman (first)
Davide Serruto (additional)
Vincent C. Tam (additional)
Derek Sturtevant (additional)
Pornphan Diraphat (additional)
Shah M. Faruque (additional)
M. Hasibur Rahman (additional)
John F. Heidelberg (additional)
Jeremy Decker (additional)
Li Li (additional)
Kate T. Montgomery (additional)
George Grills (additional)
Raju Kucherlapati (additional)
John J. Mekalanos (additional)

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Dates

Type	When
Created	20 years, 6 months ago (Feb. 22, 2005, 11:34 p.m.)
Deposited	3 years, 4 months ago (April 25, 2022, 11:05 p.m.)
Indexed	3 days, 16 hours ago (Aug. 28, 2025, 8:24 a.m.)
Issued	20 years, 6 months ago (Feb. 22, 2005)
Published	20 years, 6 months ago (Feb. 22, 2005)
Published Online	20 years, 6 months ago (Feb. 22, 2005)
Published Print	20 years, 6 months ago (March 1, 2005)

Funders 0

None

BibTeX

@article{Dziejman_2005, title={Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system}, volume={102}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0409918102}, DOI={10.1073/pnas.0409918102}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Dziejman, Michelle and Serruto, Davide and Tam, Vincent C. and Sturtevant, Derek and Diraphat, Pornphan and Faruque, Shah M. and Rahman, M. Hasibur and Heidelberg, John F. and Decker, Jeremy and Li, Li and Montgomery, Kate T. and Grills, George and Kucherlapati, Raju and Mekalanos, John J.}, year={2005}, month=feb, pages={3465–3470} }

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