DOI: 10.1073/pnas.0409558102. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2

Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2

10.1073/pnas.0409558102

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have previously shown that the putative mammalian retromer components sorting nexins 1 and 2 ( Snx1 and Snx2 ) result in embryonic lethality when simultaneously targeted for deletion in mice, whereas others have shown that Hβ58 (also known as mVps26 ), another retromer component, results in similar lethality when targeted for deletion. In the current study, we address the genetic interaction of these mammalian retromer components in mice. Our findings reveal a functional interaction between Hβ58, SNX1, and SNX2 and strongly suggest that SNX2 plays a more critical role than SNX1 in retromer activity during embryonic development. This genetic evidence supports the existence of mammalian retromer complexes containing SNX1 and SNX2 and identifies SNX2 as an important mediator of retromer biology. Moreover, we find that mammalian retromer complexes containing SNX1 and SNX2 have an essential role in embryonic development that is independent of cation-independent mannose 6-phosphate receptor trafficking.

Bibliography

Griffin, C. T., Trejo, J., & Magnuson, T. (2005). Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proceedings of the National Academy of Sciences, 102(42), 15173â15177.

Authors 3

Courtney T. Griffin (first)
JoAnn Trejo (additional)
Terry Magnuson (additional)

References 24 Referenced 70

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Dates

Type	When
Created	19 years, 10 months ago (Oct. 7, 2005, 8:24 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 10:07 a.m.)
Indexed	11 months, 4 weeks ago (Aug. 28, 2024, 2:28 p.m.)
Issued	19 years, 10 months ago (Oct. 7, 2005)
Published	19 years, 10 months ago (Oct. 7, 2005)
Published Online	19 years, 10 months ago (Oct. 7, 2005)
Published Print	19 years, 10 months ago (Oct. 18, 2005)

Funders 0

None

BibTeX

@article{Griffin_2005, title={Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2}, volume={102}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0409558102}, DOI={10.1073/pnas.0409558102}, number={42}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Griffin, Courtney T. and Trejo, JoAnn and Magnuson, Terry}, year={2005}, month=oct, pages={15173–15177} }

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