DOI: 10.1073/pnas.0406933101. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

10.1073/pnas.0406933101

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Toll-like receptor (TLR) activation is central to immunity, wherein the activation of the TLR9 subfamily members TLR9 and TLR7 results in the robust induction of type I IFNs (IFN-α/β) by means of the MyD88 adaptor protein. However, it remains unknown how the TLR signal “input” can be processed through MyD88 to “output” the induction of the IFN genes. Here, we demonstrate that the transcription factor IRF-7 interacts with MyD88 to form a complex in the cytoplasm. We provide evidence that this complex also involves IRAK4 and TRAF6 and provides the foundation for the TLR9-dependent activation of the IFN genes. The complex defined in this study represents an example of how the coupling of the signaling adaptor and effector kinase molecules together with the transcription factor regulate the processing of an extracellular signal to evoke its versatile downstream transcriptional events in a cell. Thus, we propose that this molecular complex may function as a cytoplasmic transductional-transcriptional processor.

Bibliography

Honda, K., Yanai, H., Mizutani, T., Negishi, H., Shimada, N., Suzuki, N., Ohba, Y., Takaoka, A., Yeh, W.-C., & Taniguchi, T. (2004). Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proceedings of the National Academy of Sciences, 101(43), 15416â15421.

Authors 10

Kenya Honda (first)
Hideyuki Yanai (additional)
Tatsuaki Mizutani (additional)
Hideo Negishi (additional)
Naoya Shimada (additional)
Nobutaka Suzuki (additional)
Yusuke Ohba (additional)
Akinori Takaoka (additional)
Wen-Chen Yeh (additional)
Tadatsugu Taniguchi (additional)

References 31 Referenced 411

Dates

Type	When
Created	20 years, 10 months ago (Oct. 18, 2004, 8:16 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 9:28 a.m.)
Indexed	4 days ago (Aug. 19, 2025, 6:21 a.m.)
Issued	20 years, 10 months ago (Oct. 18, 2004)
Published	20 years, 10 months ago (Oct. 18, 2004)
Published Online	20 years, 10 months ago (Oct. 18, 2004)
Published Print	20 years, 9 months ago (Oct. 26, 2004)

Funders 0

None

BibTeX

@article{Honda_2004, title={Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling}, volume={101}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0406933101}, DOI={10.1073/pnas.0406933101}, number={43}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Honda, Kenya and Yanai, Hideyuki and Mizutani, Tatsuaki and Negishi, Hideo and Shimada, Naoya and Suzuki, Nobutaka and Ohba, Yusuke and Takaoka, Akinori and Yeh, Wen-Chen and Taniguchi, Tadatsugu}, year={2004}, month=oct, pages={15416–15421} }

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