DOI: 10.1073/pnas.0405939101. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin

A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin

10.1073/pnas.0405939101

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Factors that control differentiation of presynaptic and postsynaptic elements into excitatory or inhibitory synapses are poorly defined. Here we show that the postsynaptic density (PSD) proteins PSD-95 and neuroligin-1 (NLG) are critical for dictating the ratio of excitatory-to-inhibitory synaptic contacts. Exogenous NLG increased both excitatory and inhibitory presynaptic contacts and the frequency of miniature excitatory and inhibitory synaptic currents. In contrast, PSD-95 overexpression enhanced excitatory synapse size and miniature frequency, but reduced the number of inhibitory synaptic contacts. Introduction of PSD-95 with NLG augmented synaptic clustering of NLG and abolished NLG effects on inhibitory synapses. Interfering with endogenous PSD-95 expression alone was sufficient to reduce the ratio of excitatory-to-inhibitory synapses. These findings elucidate a mechanism by which the amounts of specific elements critical for synapse formation control the ratio of excitatory-to-inhibitory synaptic input.

Bibliography

Prange, O., Wong, T. P., Gerrow, K., Wang, Y. T., & El-Husseini, A. (2004). A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proceedings of the National Academy of Sciences, 101(38), 13915â13920.

Authors 5

Oliver Prange (first)
Tak Pan Wong (additional)
Kimberly Gerrow (additional)
Yu Tian Wang (additional)
Alaa El-Husseini (additional)

References 46 Referenced 305

Dates

Type	When
Created	20 years, 11 months ago (Sept. 9, 2004, 8:24 p.m.)
Deposited	3 years, 4 months ago (April 25, 2022, 10:16 p.m.)
Indexed	2 weeks ago (Aug. 19, 2025, 7:09 a.m.)
Issued	20 years, 11 months ago (Sept. 9, 2004)
Published	20 years, 11 months ago (Sept. 9, 2004)
Published Online	20 years, 11 months ago (Sept. 9, 2004)
Published Print	20 years, 11 months ago (Sept. 21, 2004)

Funders 0

None

BibTeX

@article{Prange_2004, title={A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin}, volume={101}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0405939101}, DOI={10.1073/pnas.0405939101}, number={38}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Prange, Oliver and Wong, Tak Pan and Gerrow, Kimberly and Wang, Yu Tian and El-Husseini, Alaa}, year={2004}, month=sep, pages={13915–13920} }

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