DOI: 10.1073/pnas.0403069101. The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat

The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat

10.1073/pnas.0403069101

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The vasodilator-stimulated phosphoprotein (VASP) is a key regulator of actin dynamics. We have determined the 1.3-Å resolution crystal structure of the 45-residue-long tetramerization domain (TD) from human VASP. This domain forms a right-handed α-helical coiled-coil structure with a similar degree of supercoiling as found in the widespread left-handed coiled coils with heptad repeats. The basis for the right-handed geometry of VASP TD is a 15-residue repeat in its amino acid sequence, which reveals a characteristic pattern of hydrophobic residues. Hydrophobic interactions and a network of salt bridges render VASP TD highly thermostable with a melting point of 120°C.

Bibliography

KÃ¼hnel, K., Jarchau, T., Wolf, E., Schlichting, I., Walter, U., Wittinghofer, A., & Strelkov, S. V. (2004). The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proceedings of the National Academy of Sciences, 101(49), 17027â17032.

Authors 7

Karin Kühnel (first)
Thomas Jarchau (additional)
Eva Wolf (additional)
Ilme Schlichting (additional)
Ulrich Walter (additional)
Alfred Wittinghofer (additional)
Sergei V. Strelkov (additional)

References 49 Referenced 104

Dates

Type	When
Created	20 years, 9 months ago (Nov. 29, 2004, 8:25 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 9:37 a.m.)
Indexed	2 days, 19 hours ago (Aug. 31, 2025, 6:24 a.m.)
Issued	20 years, 9 months ago (Nov. 29, 2004)
Published	20 years, 9 months ago (Nov. 29, 2004)
Published Online	20 years, 9 months ago (Nov. 29, 2004)
Published Print	20 years, 8 months ago (Dec. 7, 2004)

Funders 0

None

BibTeX

@article{K_hnel_2004, title={The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat}, volume={101}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0403069101}, DOI={10.1073/pnas.0403069101}, number={49}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kühnel, Karin and Jarchau, Thomas and Wolf, Eva and Schlichting, Ilme and Walter, Ulrich and Wittinghofer, Alfred and Strelkov, Sergei V.}, year={2004}, month=nov, pages={17027–17032} }

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