DOI: 10.1073/pnas.0330217100. Regulated subset of G <sub>1</sub> growth-control genes in response to derepression by the Wnt pathway

Regulated subset of G 1 growth-control genes in response to derepression by the Wnt pathway

10.1073/pnas.0330217100

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Pitx2 is a bicoid-related homeodomain factor that is required for effective cell type-specific proliferation directly activating a specific growth-regulating gene cyclin D2 . Here, we report that Pitx2, in response to the Wnt/β-catenin pathway and growth signals, also can regulate c -Myc and cyclin D1. Investigation of molecular mechanisms required for Pitx2-dependent proliferation, in these cases, further supports a nuclear role for β-catenin in preventing the histone deacetylase 1-dependent inhibitory functions of several DNA-binding transcriptional repressors, potentially including E2F4/p130 pocket protein inhibitory complex, as well as lymphoid enhancer factor 1 and Pitx2, by dismissal of histone deacetylase 1 and loss of its enzymatic activity. Thus, β-catenin plays a signal-integrating role in Wnt- and growth factor-dependent proliferation events in mammalian development by both derepressing several classes of repressors and by activating Pitx2, regulating the activity of several growth control genes.

Bibliography

Baek, S. H., Kioussi, C., Briata, P., Wang, D., Nguyen, H. D., Ohgi, K. A., Glass, C. K., Wynshaw-Boris, A., Rose, D. W., & Rosenfeld, M. G. (2003). Regulated subset of G 1 growth-control genes in response to derepression by the Wnt pathway. Proceedings of the National Academy of Sciences, 100(6), 3245â3250.

Authors 10

Sung Hee Baek (first)
Chrissa Kioussi (additional)
Paola Briata (additional)
Degeng Wang (additional)
H. D. Nguyen (additional)
Kenneth A. Ohgi (additional)
Christopher K. Glass (additional)
Anthony Wynshaw-Boris (additional)
David W. Rose (additional)
Michael G. Rosenfeld (additional)

References 34 Referenced 120

Dates

Type	When
Created	22 years, 5 months ago (March 18, 2003, 6:15 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 8:46 a.m.)
Indexed	2 months, 1 week ago (June 23, 2025, 7:24 a.m.)
Issued	22 years, 5 months ago (March 10, 2003)
Published	22 years, 5 months ago (March 10, 2003)
Published Online	22 years, 5 months ago (March 10, 2003)
Published Print	22 years, 5 months ago (March 18, 2003)

Funders 0

None

BibTeX

@article{Baek_2003, title={Regulated subset of G 1 growth-control genes in response to derepression by the Wnt pathway}, volume={100}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0330217100}, DOI={10.1073/pnas.0330217100}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Baek, Sung Hee and Kioussi, Chrissa and Briata, Paola and Wang, Degeng and Nguyen, H. D. and Ohgi, Kenneth A. and Glass, Christopher K. and Wynshaw-Boris, Anthony and Rose, David W. and Rosenfeld, Michael G.}, year={2003}, month=mar, pages={3245–3250} }

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  "abstract": "<jats:p>\n            Pitx2 is a bicoid-related homeodomain factor that is required for effective cell type-specific proliferation directly activating a specific growth-regulating gene\n            <jats:italic>cyclin D2</jats:italic>\n            . Here, we report that Pitx2, in response to the Wnt/\u03b2-catenin pathway and growth signals, also can regulate c\n            <jats:italic>-Myc</jats:italic>\n            and\n            <jats:italic>cyclin D1.</jats:italic>\n            Investigation of molecular mechanisms required for Pitx2-dependent proliferation, in these cases, further supports a nuclear role for \u03b2-catenin in preventing the histone deacetylase 1-dependent inhibitory functions of several DNA-binding transcriptional repressors, potentially including E2F4/p130 pocket protein inhibitory complex, as well as lymphoid enhancer factor 1 and Pitx2, by dismissal of histone deacetylase 1 and loss of its enzymatic activity. Thus, \u03b2-catenin plays a signal-integrating role in Wnt- and growth factor-dependent proliferation events in mammalian development by both derepressing several classes of repressors and by activating Pitx2, regulating the activity of several growth control genes.\n          </jats:p>",
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