DOI: 10.1073/pnas.0307290101. The presenilins turned inside out: Implications for their structures and functions

The presenilins turned inside out: Implications for their structures and functions

10.1073/pnas.0307290101

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The presenilin (PS) proteins are polytopic integral membrane proteins that are critically involved in the development of Alzheimer's disease. The topography of the PS molecule in the endoplasmic reticulum membrane is widely accepted as exhibiting eight-hydrophobic-transmembrane (8-TM) helices. We have previously provided evidence, however, that the intact PS molecule is also present in the cell surface where it exhibits exclusively a 7-TM topography, which differs in significant structural features from the 8-TM model. This evidence, however, has been disparaged and generally rejected by researchers in Alzheimer's disease. The 7-TM model is definitively demonstrated in the present study for PS-1 at the surfaces of PS-1-transfected cells and for endogenous PS-1 at the surfaces of untransfected cells, by immunofluorescence studies using mAbs. These studies force substantial revision of current views of the structural and functional properties of the PS proteins.

Bibliography

Dewji, N. N., Valdez, D., & Singer, S. J. (2004). The presenilins turned inside out: Implications for their structures and functions. Proceedings of the National Academy of Sciences, 101(4), 1057â1062.

Authors 3

Nazneen N. Dewji (first)
Dante Valdez (additional)
S. J. Singer (additional)

References 34 Referenced 29

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Dates

Type	When
Created	21 years, 6 months ago (Jan. 27, 2004, 1:23 p.m.)
Deposited	3 years, 4 months ago (April 12, 2022, 8:47 a.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 3:14 p.m.)
Issued	21 years, 7 months ago (Jan. 19, 2004)
Published	21 years, 7 months ago (Jan. 19, 2004)
Published Online	21 years, 7 months ago (Jan. 19, 2004)
Published Print	21 years, 6 months ago (Jan. 27, 2004)

Funders 0

None

BibTeX

@article{Dewji_2004, title={The presenilins turned inside out: Implications for their structures and functions}, volume={101}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.0307290101}, DOI={10.1073/pnas.0307290101}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Dewji, Nazneen N. and Valdez, Dante and Singer, S. J.}, year={2004}, month=jan, pages={1057–1062} }

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